[Relationship between atopic factors and physical symptoms induced by gaseous formaldehyde exposure during an anatomy dissection course].
[Relationship between atopic factors and physical symptoms induced by gaseous formaldehyde exposure during an anatomy dissection course].
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[解剖解剖过程中气态甲醛暴露引起的特应性因素与身体症状之间的关系]。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
Tomiyasu Tsuda
中科院分区：
文献类型：
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作者：
Masami Mizuki;Tomiyasu Tsuda
甲醛（FA）是一种常见的室内职业性危害，常影响呼吸道.气态FA是引起多种化学敏感性的主要原因之一，在发达国家已成为一个重要的社会问题。FA浓度在解剖解剖教室被认为是高于通常情况下。近年来，我校解剖学课程中出现躯体症状的学生人数不断增加。我们计划澄清这些症状的原因。95名医学生接受了采访，使用问卷调查过敏史，身体症状的解剖过程中开发的，并与化学敏感性的症状长达三个月后，课程已经完成。我们测量了总IgE、FA特异性IgE和屋尘螨特异性IgE。百分之八十三的学生在上课期间出现过眼睛灼热、流鼻涕、喉咙痛、全身疲劳或皮肤刺激等症状。50%的学生有特应性疾病病史。58%的学生对屋尘螨特异性IgE检测呈阳性;然而，只有一名学生在课程期间没有抱怨任何症状，对FA-IgE检测呈阳性。有特应性因素（目前有特应性疾病史和较高的总IgE）和/或化学敏感性的学生在解剖解剖过程中表现出比无此类病史的学生更差的身体症状。总之，它表明，气态FA暴露可能会加剧基本的过敏症状，此外，与化学敏感性的人表现出更严重的症状后，气态FA暴露。然而，在我们的研究中，我们发现FA-IgE和身体症状的气体FA暴露期间或之后的解剖解剖过程中没有关系。
Formaldehyde (FA) is an occupational and general indoor hazard often affecting the respiratory airways. One of the main causes of multiple chemical sensitivity is gaseous FA, and it has become an important social problem in developed countries. FA concentrations in anatomy dissection classrooms are thought to be higher than under usual circumstances. The number of students developing physical symptoms during the anatomy dissection course in our university has been increasing over recent years. We planned to clarify the causes of such symptoms. Ninety-five medical students were interviewed using a questionnaire about allergic histories, physical symptoms developed during the anatomy dissection course, and symptoms related to chemical sensitivity up to three months after the course had finished. We measured total IgE, specific IgE to FA and specific IgE to house dust mites. Eighty-three percent of students had experienced symptoms, such as burning eyes, nasal discharge, sore throat, general fatigue or skin irritation during the course. Fifty percent of students had a past history of atopic disease. Fifty-eight percent of students tested positive to specific IgE to house dust mites; however, only one student, who did not complain of any symptoms during the course, tested positive to FA-IgE. Students with atopic factors (present histories of atopic diseases and higher total IgE) and/or chemical sensitivity demonstrated worse physical symptoms during the anatomy dissection course than students without such histories. In conclusion, it is suggested that gaseous FA exposure may exacerbate basic allergic symptoms, and moreover that people with chemical sensitivity demonstrated worse symptoms following gaseous FA exposure. Nevertheless, in our study we find no relationship between FA-IgE and the physical symptoms of gaseous FA exposure during or following an anatomy dissection course.