The nucleus reuniens, a thalamic relay for cortico-hippocampal interaction in recent and remote memory consolidation
The nucleus reuniens, a thalamic relay for cortico-hippocampal interaction in recent and remote memory consolidation
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DOI：
10.1016/j.neubiorev.2021.02.025
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发表时间：
2021-03-06
影响因子：
8.2
通讯作者：
Quilichini, Pascale P.
中科院分区：
文献类型：
--
作者：
Ferraris, Maeva;Cassel, Jean-Christophe;Quilichini, Pascale P.
陈述性记忆的巩固被认为主要发生在睡眠期间，涉及两个大脑区域之间的对话，海马体和内侧前额叶皮层。在经历过程中由神经元集合体编码的信息在睡眠期间重放，导致记忆痕迹在前额叶皮层中的逐步加强和整合。信息从海马逐渐转移到内侧前额叶皮层进行长期存储，需要皮层-海马网络通过不同的振荡（如波纹、纺锤波和慢振荡）实现同步。最近的研究表明，第三个伙伴，核reuniens，参与记忆巩固。它与海马体和内侧前额叶皮层的双向连接使团聚体处于在两个结构之间传递信息的关键位置。事实上，许多专题研究揭示了重聚核在不同的最近和遥远记忆巩固中的原始作用。本文旨在探讨这些贡献，以及它在这个复杂的记忆网络的功能嵌入，并提供一些见解的可能机制。
The consolidation of declarative memories is believed to occur mostly during sleep and involves a dialogue between two brain regions, the hippocampus and the medial prefrontal cortex. The information encoded during experience by neuronal assemblies is replayed during sleep leading to the progressive strengthening and integration of the memory trace in the prefrontal cortex. The gradual transfer of information from the hippocampus to the medial prefrontal cortex for long-term storage requires the synchronization of cortico-hippocampal networks by different oscillations, like ripples, spindles, and slow oscillations. Recent studies suggest the involvement of a third partner, the nucleus reuniens, in memory consolidation. Its bidirectional connections with the hippocampus and medial prefrontal cortex place the reuniens in a key position to relay information between the two structures. Indeed, many topical works reveal the original role that the nucleus reuniens occupies in different recent and remote memories consolidation. This review aimed to examine these contributions, as well as its functional embedment in this complex memory network, and provide some insights on the possible mechanisms.