Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii
Vertebrate-type intron-rich genes in the marine annelid Platynereis dumerilii
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DOI：
10.1126/science.1119089
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发表时间：
2005-11-25
期刊：
影响因子：
56.9
通讯作者：
Arendt, D
中科院分区：
文献类型：
--
作者：
Raible, F;Tessmar-Raible, K;Arendt, D
之前的基因组比较表明，脊椎动物进化的一个重要趋势是内含子丰度的急剧增加。通过使用海洋环节动物 Platynereis dumerilii 的基因组数据和表达序列标签，我们提供了直接证据，表明大约三分之二的人类内含子早于两侧对称动物的辐射，但在很大程度上从昆虫和线虫基因组中丢失了。编码外显子序列的比较证实了扁沙蚕和人类基因的祖先性质。因此，乌贝类祖先拥有复杂的、富含内含子的基因，这些基因在扁沙蚕和人类中都保留了下来。
Previous genome comparisons have suggested that one important trend in vertebrate evolution has been a sharp rise in intron abundance. By using genomic data and expressed sequence tags from the marine annelid Platynereis dumerilii, we provide direct evidence that about two-thirds of human introns predate the bilaterian radiation but were lost from insect and nematode genomes to a large extent. A comparison of coding exon sequences confirms the ancestral nature of Platynereis and human genes. Thus, the urbilaterian ancestor had complex, intron-rich genes that have been retained in Platynereis and human.