Lung Adenocarcinoma and Squamous Cell Carcinoma Gene Expression Subtypes Demonstrate Significant Differences in Tumor Immune Landscape.
Lung Adenocarcinoma and Squamous Cell Carcinoma Gene Expression Subtypes Demonstrate Significant Differences in Tumor Immune Landscape.
复制标题
DOI：
10.1016/j.jtho.2017.03.010
复制
发表时间：
2017-06
期刊：
影响因子：
--
通讯作者：
Lai-Goldman M
中科院分区：
文献类型：
--
作者：
Faruki H;Mayhew GM;Serody JS;Hayes DN;Perou CM;Lai-Goldman M
肺腺癌（AD）和肺鳞状细胞癌（SCC）的分子亚型揭示了在基因组和临床属性方面不同的生物学多样性肿瘤。已发表的免疫细胞特征和几个肺AD和SCC基因表达数据集，包括癌症基因组图谱，用于检查与AD和SCC表达亚型相关的免疫应答。在肿瘤微环境中研究了免疫细胞群和其他免疫相关基因（包括CD 274分子基因（CD 274）（程序性死亡配体1））相对于AD（终末呼吸单位、近端增殖和近端炎症）和SCC（原始、经典、分泌和基底）亚型表达亚型的表达。肺AD和SCC表达亚型在肿瘤免疫景观中表现出显著差异。AD的近端增殖亚型在AD中表现出低免疫细胞表达，而分泌亚型在SCC中表现出升高的免疫细胞表达。在SCC肿瘤中，肿瘤表达亚型是比CD 274（程序性死亡配体1）更好的免疫细胞表达预测因子，但在AD肿瘤中是相当的预测因子。非沉默突变负荷与各亚型的免疫细胞表达无关;然而，主要组织相容性复合物II类基因表达与免疫细胞表达高度相关。增加免疫和主要组织相容性复合体II基因表达与改善生存在终端呼吸单位和近端炎症亚型的AD和原始亚型的SCC。肺AD和SCC的分子表达亚型证明了免疫宿主应答的关键和可重复的差异。应研究肿瘤表达亚型作为免疫治疗潜在生物标志物的评价。
Molecular subtyping of lung adenocarcinoma (AD) and lung squamous cell carcinoma (SCC) reveal biologically diverse tumors that vary in their genomic and clinical attributes. Published immune cell signatures and several lung AD and SCC gene expression data sets, including The Cancer Genome Atlas, were used to examine immune response in relation to AD and SCC expression subtypes. Expression of immune cell populations and other immune related genes, including CD274 molecule gene (CD274) (programmed death ligand 1), was investigated in the tumor microenvironment relative to the expression subtypes of the AD (terminal respiratory unit, proximal proliferative, and proximal inflammatory) and SCC (primitive, classical, secretory, and basal) subtypes. Lung AD and SCC expression subtypes demonstrated significant differences in tumor immune landscape. The proximal proliferative subtype of AD demonstrated low immune cell expression among ADs whereas the secretory subtype showed elevated immune cell expression among SCCs. Tumor expression subtype was a better predictor of immune cell expression than CD274 (programmed death ligand 1) in SCC tumors but was a comparable predictor in AD tumors. Nonsilent mutation burden was not correlated with immune cell expression across subtypes; however, major histocompatibility complex class II gene expression was highly correlated with immune cell expression. Increased immune and major histocompatibility complex II gene expression was associated with improved survival in the terminal respiratory unit and proximal inflammatory subtypes of AD and in the primitive subtype of SCC. Molecular expression subtypes of lung AD and SCC demonstrate key and reproducible differences in immune host response. Evaluation of tumor expression subtypes as potential biomarkers for immunotherapy should be investigated.
登录
查看更多内容
影响因子：
28.2
作者：
Chen PL;Roh W;Reuben A;Cooper ZA;Spencer CN;Prieto PA;Miller JP;Bassett RL;Gopalakrishnan V;Wani K;De Macedo MP;Austin-Breneman JL;Jiang H;Chang Q;Reddy SM;Chen WS;Tetzlaff MT;Broaddus RJ;Davies MA;Gershenwald JE;Haydu L;Lazar AJ;Patel SP;Hwu P;Hwu WJ;Diab A;Glitza IC;Woodman SE;Vence LM;Wistuba II;Amaria RN;Kwong LN;Prieto V;Davis RE;Ma W;Overwijk WW;Sharpe AH;Hu J;Futreal PA;Blando J;Sharma P;Allison JP;Chin L;Wargo JA
通讯作者：
Wargo JA
DOI：
10.1158/1078-0432.ccr-10-0199
发表时间：
2010-10-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Wilkerson MD;Yin X;Hoadley KA;Liu Y;Hayward MC;Cabanski CR;Muldrew K;Miller CR;Randell SH;Socinski MA;Parsons AM;Funkhouser WK;Lee CB;Roberts PJ;Thorne L;Bernard PS;Perou CM;Hayes DN
通讯作者：
Hayes DN
影响因子：
64.5
作者：
Rooney MS;Shukla SA;Wu CJ;Getz G;Hacohen N
通讯作者：
Hacohen N
影响因子：
8
作者：
Schabath MB;Welsh EA;Fulp WJ;Chen L;Teer JK;Thompson ZJ;Engel BE;Xie M;Berglund AE;Creelan BC;Antonia SJ;Gray JE;Eschrich SA;Chen DT;Cress WD;Haura EB;Beg AA
通讯作者：
Beg AA
DOI：
10.1056/nejmoa1504627
发表时间：
2015-07-09
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer J;Reckamp KL;Baas P;Crinò L;Eberhardt WE;Poddubskaya E;Antonia S;Pluzanski A;Vokes EE;Holgado E;Waterhouse D;Ready N;Gainor J;Arén Frontera O;Havel L;Steins M;Garassino MC;Aerts JG;Domine M;Paz-Ares L;Reck M;Baudelet C;Harbison CT;Lestini B;Spigel DR
通讯作者：
Spigel DR