Synthetic octacalcium phosphate: A possible carrier for mesenchymal stem cells in bone regeneration.
Synthetic octacalcium phosphate: A possible carrier for mesenchymal stem cells in bone regeneration.
复制标题
合成磷酸八钙：骨再生中间充质干细胞的可能载体。
DOI：
10.1109/embc.2013.6609520
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Anada T
中科院分区：
文献类型：
--
作者：
Suzuki O;Anada T
本文综述了合成磷酸八钙（OCP）作为成骨细胞支架的生物材料研究进展。OCP晶体被认为是骨和牙齿中羟基磷灰石（HA）晶体形成的前驱相之一。近年来，大量的生物材料和组织工程研究利用合成OCP揭示了OCP作为生物活性材料和合成透明质酸材料的潜在功能，因为它具有高度的骨导电性和可生物降解性。体外研究表明，OCP晶体对成骨细胞分化具有积极作用。体内研究证实，如果将颗粒形式的OCP材料和含有天然聚合物（如明胶和胶原蛋白）的OCP基复合材料植入各种具有临界尺寸直径的骨缺损模型（定义为在动物一生中不能自发愈合的缺损），则可以增强骨再生。OCP的一个特殊特征是在生理条件下OCP向透明质酸的逐步转化，这是一种促进体内骨再生的机制。OCP-HA转化伴随着材料性质的渐进物理化学变化，影响到成骨细胞所在晶体周围的组织反应。在ocp基材料中植入间充质干细胞（MSCs）对大鼠临界尺寸颅骨缺损的骨再生的促进作用强于单独使用ocp基材料。综上所述，OCP晶体对成骨细胞包括骨髓间充质干细胞的体内分化有影响。介绍了在实验室通过实验收集到的证据。
The present paper reviews biomaterial studies of synthetic octacalcium phosphate (OCP) as a scaffold of osteoblastic cells. OCP crystals have been suggested to be one of precursor phases in hydroxyapatite (HA) crystal formation in bone and tooth. The recent intensive biomaterials and tissue engineering studies using synthetic OCP disclosed the potential function of OCP as a bioactive material as well as synthetic HA materials due to its highly osteoconductive and biodegradable properties. In vitro studies showed that OCP crystals exhibit a positive effect on osteoblastic cell differentiation. In vivo studies confirmed that the materials of OCP in a granule forms and OCP-based composite materials with natural polymers, such as gelatin and collagen, enhance bone regeneration if implanted in various model bone defects with critical-sized diameters, defined as a defect which does not heal spontaneously throughout the lifetime of the animals. One of particular characteristics of OCP, found as a mechanism to enhance bone regeneration in vivo, is a process of progressive conversion from OCP to HA at physiological conditions. The OCP-HA conversion is accompanied by progressive physicochemical changes of the material properties, which affects the tissue reaction around the crystals where osteoblastic cells are encountered. Mesenchymal stem cells (MSCs) seeded in an OCP-based material enhanced bone regeneration in the rat critical-sized calvaria defect more than that by the material alone. The overall results reveal that OCP crystals have an effect on osteoblastic cell differentiation including the differentiation of MSCs in vivo. The evidence collected experimentally in the laboratory was presented.