CHEMOTHERAPY COMBINED WITH OR WITHOUT HYPERTHERMIA FOR PATIENTS WITH ESOPHAGEAL-CARCINOMA - A PROSPECTIVE RANDOMIZED TRIAL
CHEMOTHERAPY COMBINED WITH OR WITHOUT HYPERTHERMIA FOR PATIENTS WITH ESOPHAGEAL-CARCINOMA - A PROSPECTIVE RANDOMIZED TRIAL
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DOI：
10.3109/02656739409009352
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发表时间：
1994-07-01
影响因子：
3.1
通讯作者：
OSHIUMI, Y
中科院分区：
文献类型：
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作者：
SUGIMACHI, K;KUWANO, H;OSHIUMI, Y
自1990年至1991年，40例胸段食管鳞状细胞癌患者被收治到我院，化疗（油博莱霉素口服）。和CDDP d.i.v.）在一项前瞻性随机试验中，进行了联合或不联合热疗，以研究热疗的效果。两组（A组，由20名仅接受化疗的患者组成; B组，由20名接受化疗和热疗的患者组成）在各种预后因素方面具有可比性。在上述治疗方案后，分别在A组和B组的16名和17名患者中进行食管切除术。A组和B组中分别有8例（40.0%）和14例（70.0%）患者吞咽困难主观改善，而影像学改善分别为5例（25.0%）和10例（50.0%）。分别在16例（A组）和17例（B组）患者的切除标本中，A组和B组分别有3例（18.8%）和7例（41.2%）的组织病理学证据表明治疗有效。排除浅表癌（T1肿瘤）病例。A组和B组中分别有2例（14.3%）和7例（58.3%）确认了治疗的组织学有效性（p < 0.05）。两组之间的副作用发生率没有差异。因此，热疗联合化疗组的临床和病理效果良好，特别是对中晚期食管癌。
From 1990 to 1991, 40 patients with squamous cell carcinoma of the thoracic oesophagus were admitted to our institutions and chemotherapy (oil Bleomycin p.o. and CDDP d.i.v.) either combined with or without hyperthermia was performed, in a prospective randomized trial carried out to investigate the effects of hyperthermia. The two groups (group A, consisting of 20 patients given chemotherapy alone; and group B, made up of 20 given chemotherapy with hyperthermia) were comparable with regard to various prognostic factors. Following the above treatment regimens, an oesophagectomy was done in 16 and 17 patients from groups A and B, respectively. A subjective improvement of dysphagia was seen in 8 (40.0%), and in 14 patients (70.0%), while a radiographic improvement was recognized in 5 (25.0%) and 10 cases (50.0%) in groups A and B. respectively. In the resected specimen of 16 (group A) and 17 patients (group B), histopathological evidence of the effectiveness of the treatments were recognized in 3 (18.8%) and 7 (41.2%) from groups A and B, respectively. Excluding the cases of superficial carcinoma (T1 tumour). histologic effectiveness of the treatments were recognized in 2 (14.3%) and 7 (58.3%) in groups A and B, respectively (p < 0.05). There was no difference in the occurrence of side effects between the groups. Therefore, the clinical and pathological effects were favourable in the hyperthermia combined with chemotherapy group, especially in the cases with advanced oesophageal cancer.