Pathogenesis of Rinderpest Virus Infection in Rabbits II. Effect of Rinderpest Virus on the Immune Functions of Rabbits
Pathogenesis of Rinderpest Virus Infection in Rabbits II. Effect of Rinderpest Virus on the Immune Functions of Rabbits
复制标题
兔牛瘟病毒感染的发病机制II。
DOI：
10.1128/iai.9.2.206-211.1974
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发表时间：
1974
影响因子：
3.1
通讯作者：
F. Chino
中科院分区：
文献类型：
--
作者：
K. Yamanouchi;A. Fukuda;F. Kobune;Y. Yoshikawa;F. Chino
牛瘟病毒感染可诱导兔体液抗体反应和细胞介导免疫的显著抑制。该病毒对一抗反应表现出抑制作用，其表现为斑块形成细胞（免疫球蛋白[Ig]M）数量的减少以及IgM和IgG类型的绵羊红细胞的血凝抗体滴度的降低，而该病毒对记忆细胞的产生没有可检测到的影响。病毒诱导的细胞介导的免疫抑制表现为外周淋巴细胞对植物血凝素刺激的增殖反应速率降低，以及对纯化蛋白衍生物的延迟型皮肤反应的抑制。这种抑制作用可持续14天或更长时间。未观察到网状内皮系统吞噬活性的改变。讨论了病毒诱导的淋巴组织组织学病变与病毒诱导的免疫抑制的相关性。
Rinderpest virus infection was shown to induce marked suppression of both humoral antibody response and cell-mediated immunity in rabbits. The virus exhibited a suppressive effect on primary antibody response as indicated by a decrease in numbers of plaque-forming cells (immunoglobulin [Ig]M) and hemagglutinating antibody titers of both IgM and IgG types to sheep red blood cells, whereas there was no detectable effect of the virus on the production of memory cells. Virus-induced suppression of cell-mediated immunity was demonstrated by a decreased rate of proliferative response of peripheral lymphocytes to phytohemagglutinin stimulus and by a depression of delayed-type skin reactions to purified protein derivative. Such suppressive effects were indicated to persist for 14 days or longer. Alteration in phagocytic activity of the reticuloendothelial system was not observed. The relevance of the virus-induced histological lesions in the lymphoid tissues to the virus-induced immunosuppression was discussed.