Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy.
Epidemiological and experimental studies on a new incident of transmissible mink encephalopathy.
复制标题
一起新发传染性水貂脑病的流行病学和实验研究。
DOI：
--
复制
发表时间：
1991
影响因子：
3.8
通讯作者：
G. R. Hartsough
中科院分区：
文献类型：
--
作者：
R. F. Marsh;R. Bessen;Scott Lehmann;G. R. Hartsough
对1985年美国威斯康星州斯泰森维尔发生的水貂传染性脑病（transmissible mink encephalopathy，TME）新病例的流行病学调查表明，水貂饲养场主从未给水貂喂过羊产品，而是喂过大量的倒下或生病的奶牛产品。为了调查TME的发生可能是由于暴露于受感染的牛，两只荷斯坦公牛小牛脑内注射貂脑从Stetsonville牧场。每头公牛在接种后18个月和19个月分别发生了致命的海绵状脑病，并且通过脑内或口服接种将牛脑传回到水貂中具有高致病性。这些结果表明，在美国的牛中存在以前未被识别的羊瘙痒病样感染。
Epidemiological investigation of a new incident of transmissible mink encephalopathy (TME) in Stetsonville, Wisconsin, U.S.A. in 1985 revealed that the mink rancher had never fed sheep products to his mink but did feed them large amounts of products from fallen or sick dairy cattle. To investigate the possibility that this occurrence of TME may have resulted from exposure to infected cattle, two Holstein bull calves were injected intracerebrally with mink brain from the Stetsonville ranch. Each bull developed a fatal spongiform encephalopathy 18 and 19 months after inoculation, respectively, and both bovine brains passaged back into mink were highly pathogenic by either intracerebral or oral inoculation. These results suggest the presence of a previously unrecognized scrapie-like infection in cattle in the United States.