Getting his act together: Roles of glutamate, nitric oxide, and dopamine in the medial preoptic area
Getting his act together: Roles of glutamate, nitric oxide, and dopamine in the medial preoptic area
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DOI：
10.1016/j.brainres.2006.08.031
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发表时间：
2006-12-18
期刊：
影响因子：
2.9
通讯作者：
Dominguez, Juan M.
中科院分区：
文献类型：
--
作者：
Hull, Elaine M.;Dominguez, Juan M.
性腺激素主要是缓慢的，基因组介导的影响，但交配需要与伴侣快速互动。激素促进男性性行为的一个主要方式是通过增加神经递质受体或调节神经递质合成或释放的酶的产生。多巴胺是一种重要的易化性神经递质，内侧视前区（MPOA）是男性性行为的重要整合部位。MPOA多巴胺在交配前和交配期间释放，促进交配，生殖器反射和性动机。性腺激素调节多巴胺的释放在MPOA的雄性大鼠部分通过增加一氧化氮合酶（NOS）的MPOA;由此产生的增加一氧化氮（NO）的生产增加基础和女性刺激的多巴胺释放。谷氨酸还通过增加NO的产生增加多巴胺的释放。至少有一些MPOA的aminamatergic输入来自内侧杏仁核（MeA）和终纹床核（BNST），介导女性刺激的多巴胺增加，这反过来又增强了交配能力。MPOA中的细胞外谷氨酸在交配期间增加，特别是在射精期间，并且增加的谷氨酸促进交配和生殖器反射。先前的性经验也有助于交配，并赋予抵抗各种损伤，药物和压力的损害。经验增强性刺激的处理，其作用需要激活MPOA中的谷氨酸NMDA受体和NOS。有经验的男性MPOA中神经元NOS增加。因此，谷氨酸、NO和多巴胺在MPOA中相互作用，以促进交配并增强未来的性反应。(c)2006 Elsevier B. V.保留所有权利。
Gonadal hormones have primarily slow, genomically mediated effects, but copulation requires rapid interactions with a partner. A major way in which hormones facilitate male sexual behavior is by increasing production of neurotransmitter receptors or of enzymes that regulate neurotransmitter synthesis or release. Dopamine is an important facilitative neurotransmitter, and the medial preoptic area (MPOA) is a critical integrative site for male sexual behavior. MPOA dopamine is released before and during mating and facilitates copulation, genital reflexes, and sexual motivation. Gonadal hormones regulate dopamine release in the MPOA of male rats in part by increasing nitric oxide synthase (NOS) in the MPOA; the resultant increase in production of nitric oxide (NO) increases both basal and female-stimulated dopamine release. Glutamate also increases dopamine release via increased production of NO. At least some of the glutamatergic inputs to the MPOA are from the medial amygdala (MeA) and bed nucleus of the stria terminalis (BNST), which mediate the female-stimulated increase in dopamine, which in turn enhances copulatory ability. Extracellular glutamate in the MPOA increases during copulation, especially during ejaculation, and increased glutamate facilitates copulation and genital reflexes. Previous sexual experience also facilitates copulation and confers resistance to impairment by various lesions, drugs, and stress. Experience enhances processing of sexual stimuli, and its effects require activation of glutamate NMDA receptors and NOS in the MPOA. Neuronal NOS is increased in the MPOA of experienced males. Therefore, glutamate, NO, and dopamine interact in the MPOA to facilitate mating and to enhance future sexual responsiveness. (c) 2006 Elsevier B.V. All rights reserved.