Microbial genes in the human genome: Lateral transfer or gene loss?
Microbial genes in the human genome: Lateral transfer or gene loss?
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DOI：
10.1126/science.1061036
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发表时间：
2001-06-08
期刊：
影响因子：
56.9
通讯作者：
Eisen, JA
中科院分区：
文献类型：
--
作者：
Salzberg, SL;White, O;Eisen, JA
对人类基因组进行了分析，以寻找基因从原核生物侧向转移到基因组中的证据。对人类、果蝇、线虫、酵母、芥菜、真核寄生虫和所有完整的原核生物基因组的蛋白质组进行蛋白质序列比较，并收集人类和其他各组生物之间共有的所有基因。大约有40个基因被发现是人类和细菌独有的，是从细菌到脊椎动物水平转移的候选例子。基因丢失结合样本量效应和进化速率变异提供了另一种生物学上更合理的解释。
The human genome was analyzed for evidence that genes had been Laterally transferred into the genome from prokaryotic organisms. Protein sequence comparisons of the proteomes of human, fruit fly, nematode worm, yeast, mustard weed, eukaryotic parasites, and all completed prokaryote genomes were performed, and all genes shared between human and each of the other groups of organisms were collected. About 40 genes were found to be exclusively shared by humans and bacteria and are candidate examples of horizontal transfer from bacteria to vertebrates. Gene Loss combined with sample size effects and evolutionary rate variation provide an alternative, more biologically plausible explanation.