Modulation of synapse formation by cyclic adenosine monophosphate.

Modulation of synapse formation by cyclic adenosine monophosphate.
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环单磷酸腺苷调节突触形成。

DOI:
10.1126/science.6314503
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发表时间:
1983
期刊:
影响因子:
56.9
通讯作者:
M. Adler
M. Adler
中科院分区:
综合性期刊1区
文献类型:
--
作者:
M. Nirenberg;S. Wilson;H. Higashida;A. Rotter;K. Krueger;N. Busis;R. Ray;J. Kenimer;M. Adler

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神经母细胞瘤杂交细胞和肌管之间的突触表现出高度的可塑性。增加环磷酸腺苷(AMP)水平的杂交细胞数天的结果在功能性电压敏感性钙通道,这是所需的诱发分泌乙酰胆碱的外观。结果表明,cAMP通过调节电压敏感性Ca ~(2+)通道的表达来调节突触发生,并表明cAMP影响某些糖蛋白的翻译后修饰和某些蛋白质的细胞水平。
Synapses between neuroblastoma-hybrid cells and myotubes exhibit a high degree of plasticity. Increase of cyclic adenosine monophosphate (AMP) levels of the hybrid cells for several days results in the appearance of functional voltage-sensitive Ca2+ channels, which are required for evoked secretion of acetylcholine. The results show that cyclic AMP regulates synaptogenesis by regulating the expression of voltage-sensitive Ca2+ channels, and suggest that cyclic AMP affects posttranslational modifications of some glycoproteins and cellular levels of certain proteins.
DOI: --
发表时间: 1983
期刊: The Journal of biological chemistry
影响因子: --
作者:
Curtis,BM;Catterall,WA
通讯作者: Catterall,WA
DOI: --
发表时间: 1983
期刊: The Journal of biological chemistry
影响因子: --
作者:
Venter,JC;Fraser,CM;Schaber,JS;Jung,CY;Bolger,G;Triggle,DJ
通讯作者: Triggle,DJ
DOI: --
发表时间: 1981
期刊: The Journal of biological chemistry
影响因子: --
作者:
Weber,MJ
通讯作者: Weber,MJ