No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
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DOI：
10.1176/appi.ajp.162.2.383
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发表时间：
2005-02-01
影响因子：
17.7
通讯作者：
Charney, DS
中科院分区：
文献类型：
--
作者：
Bonne, O;Bain, E;Charney, DS
目的：5-羟色胺1A型受体（5-HT 1AR）已被证明在实验动物中受到压力的影响，并与人类的焦虑和抑郁有关。在本研究中，作者寻求5-HT 1AR结合与创伤后应激障碍（PTSD）之间的联系。方法：采用正电子发射断层扫描和放射性配体[F-18] FCWAY，作者比较了PTSD患者和健康受试者之间的5-HT 1AR结合。结果：未发现5-HT 1AR分布容积、结合电位或示踪剂递送的显著差异。结论：PTSD患者的5-HT 1AR表达可能没有改变。
Objective: Serotonin type 1A receptors (5HT1ARs) have been shown to be affected by stress in experimental animals and related to anxiety and depression in humans. In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder ( PTSD).Method: Using positron emission tomography and the radioligand [F-18] FCWAY, the authors compared 5HT1AR binding between patients with PTSD and healthy subjects.Results: No significant differences in 5HT1AR distribution volume, binding potential, or tracer delivery were found.Conclusions: 5HT1AR expression may not be altered in patients with PTSD.