Ethanol inhibition of synaptosomal high-affinity choline uptake.
Ethanol inhibition of synaptosomal high-affinity choline uptake.
复制标题
乙醇抑制突触体高亲和力胆碱的摄取。
DOI：
10.1016/0014-2999(88)90691-7
复制
发表时间：
1988
影响因子：
5
通讯作者：
North,PE
中科院分区：
文献类型：
--
作者：
Mrak,RE;North,PE
乙醇在体外抑制突触体钠依赖性，高亲和力胆碱摄取，在乙酰胆碱合成的限速步骤。这种抑制发生在乙醇浓度低至50 mM时，是可逆的，并且不归因于乙醇对突触体膜电位的影响。相比之下，乙醇浓度高达400 mM对突触体高亲和力摄取γ-氨基丁酸（中枢神经系统中的一种主要抑制性神经递质）没有影响。所观察到的乙醇抑制胆碱摄取是一致的建议，抑郁症的胆碱能系统是重要的急性乙醇中毒。
Ethanol in vitro inhibited synoptosomal sodium-dependent, high-affinity choline uptake, the rate-limiting step in the synthesis of acetylcholine. This inhibition occurred with ethanol concentrations as low as 50 mM, was reversible and was not attributable to ethanol effects on synaptosomal membrane potential. In contrast, ethanol concentrations as high as 400 mM had no effect on synaptosomal high-affinity uptake of γ-aminobutyric acid, a major inhibitory neurotransmitter in the central nervous system. The observed ethanol inhibition of choline uptake is consistent with suggestions that depression of cholinergic systems is important in acute ethanol intoxication.