Myocardial effects of ethanol consumption in the rat with streptozotocin-induced diabetes.
Myocardial effects of ethanol consumption in the rat with streptozotocin-induced diabetes.
复制标题
链脲佐菌素诱导的糖尿病大鼠乙醇消耗对心肌的影响。
DOI：
10.1097/01.alc.0000024128.90275.b3
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Allen,Gayle
中科院分区：
文献类型：
--
作者：
Giles,ThomasD;Given,MichaelB;Greenberg,StanS;Zhao,Xinfang;Kerut,EdmundKenneth;McElwain,Elizabeth;Allen,Gayle
BackgroundRats with streptozotocin (STZ)‐induced diabetes exhibit alterations in cardiac function, ventricular remodeling, and changes in cell signaling, which includes protein kinase C (PKC) isoforms. Moderate consumption of ethanol has a beneficial effect on cardiovascular outcomes in the general population, an effect that has recently been found to extend to patients with diabetes mellitus. We studied the effect of low‐dose ethanol consumption on cardiac function, geometry, and PKC isoforms in the rat with STZ‐induced diabetes.MethodsFour groups of rats were studied over 8 to 10 weeks: control, STZ‐induced diabetes, 12% (v/v) ethanol consumption, and STZ‐induced diabetes plus 4% (v/v) ethanol consumption. Invasive hemodynamic measurements were performed; myocardial tissue was obtained for analysis for total PKC and cytosolic and membrane protein content of PKC‐α, PKC‐δ, and PKC‐ε, and two‐dimensional and M‐mode echocardiograms were obtained.ResultsCompared with rats with diabetes alone, consumption of 4% ethanol prevented the decrease in left ventricular dP/dt seen with diabetes alone, as well as the increase in left ventricular internal dimension. Up‐regulation of PKC‐α, ‐δ, and ‐ε occurring in the diabetic animals was also prevented by ethanol consumption, whereas ethanol alone had no effect on PKC isoform pattern.ConclusionsThese data suggest that STZ‐induced cardiac remodeling and dysfunction are associated with increases in PKC activity, particularly PKC‐α, ‐δ, and ‐ε, and that consumption of ethanol can prevent these changes.
