A Comparison of Genotype-Phenotype Maps for RNA and Proteins
A Comparison of Genotype-Phenotype Maps for RNA and Proteins
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DOI：
10.1016/j.bpj.2012.01.047
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发表时间：
2012-04-18
影响因子：
3.4
通讯作者：
Wagner, Andreas
中科院分区：
文献类型：
--
作者：
Ferrada, Evandro;Wagner, Andreas
大分子的基因型（序列）和表型（结构）之间的关系影响其进化新结构和功能的能力。我们在这里比较蛋白质和 RNA 分子的基因型空间组织，以确定可能影响这种能力的差异。为此，我们通过计算研究了短RNA和减小单体字母大小的晶格蛋白的基因型-表型关系，以使其基因型空间的详尽分析和直接比较变得可行。我们发现折叠的蛋白质分子比 RNA 分子少得多，但它们折叠成的结构比 RNA 多得多。因此，蛋白质表型具有较小的基因型网络，其成员基因型往往比 RNA 表型更相似。 RNA 分子周围给定半径的序列空间中的邻域比蛋白质分子包含更多新颖的结构。我们将这一特性与天然 RNA 和蛋白质分子的证据进行比较，并得出结论：RNA 基因型空间可能更有利于新结构表型的进化。
The relationship between the genotype ( sequence) and the phenotype ( structure) of macromolecules affects their ability to evolve new structures and functions. We here compare the genotype space organization of proteins and RNA molecules to identify differences that may affect this ability. To this end, we computationally study the genotype-phenotype relationship for short RNA and lattice proteins of a reduced monomer alphabet size, to make exhaustive analysis and direct comparison of their genotype spaces feasible. We find that many fewer protein molecules than RNA molecules fold, but they fold into many more structures than RNA. In consequence, protein phenotypes have smaller genotype networks whose member genotypes tend to be more similar than for RNA phenotypes. Neighborhoods in sequence space of a given radius around an RNA molecule contain more novel structures than for protein molecules. We compare this property to evidence from natural RNA and protein molecules, and conclude that RNA genotype space may be more conducive to the evolution of new structure phenotypes.