Correspondence between secular changes in alcohol dependence and age of drinking onset among women in the United States
Correspondence between secular changes in alcohol dependence and age of drinking onset among women in the United States
复制标题
DOI：
10.1111/j.1530-0277.2008.00719.x
复制
发表时间：
2008-08-01
影响因子：
3.2
通讯作者：
Bierut, Laura J.
中科院分区：
文献类型：
--
作者：
Grucza, Richard A.;Norberg, Karen;Bierut, Laura J.
背景：几条线索的证据表明，近几十年来，女性酒精依赖的终生患病率有所上升，但对男性来说没有显著上升。早期饮酒（AOD）与酒精依赖风险密切相关，有证据表明，平均AOD也有所下降，尤其是女性。本报告试图确认过度酒精依赖症的趋势，并确定它们在多大程度上可能解释酒精依赖症的长期趋势。方法：对2个大型国家流行病学调查的数据进行重复横断面分析，以在控制年龄相关因素的同时估计跨队列差异。在将AOD作为协变量纳入之前和之后，使用回归分析来计算与出生队列成员相关的酒精依赖风险。结果：1944年至1963年间出生的男性和女性都比最早出生的队列（1934-43）更早开始饮酒。然而，女性AOD的净减少量（3.2年）是男性（1.6年）的两倍。在调整了AOD后，不同出生队列女性的终生患病率差异变得不显著，表明AOD在酒精依赖终生患病率的变化中占很大一部分。结论：这些结果表明，AOD的减少是女性终生酒精依赖增加的主要原因。AOD可能是动态的，因此可改变的风险行为影响酒精依赖风险的一个指标。
Background: Several lines of evidence suggest that the lifetime prevalence of alcohol dependence among women has increased in recent decades, but has not risen, significantly for men. Early age at onset of drinking (AOD) is strongly correlated with risk for alcohol dependence and there is evidence that mean AOD has also decreased, particularly for women. The present report sought to confirm the trends in AOD and to determine the extent to which they might account for secular trends in alcohol dependence.Methods: Repeated cross-sectional analyses of data from 2 large, national epidemiological surveys were conducted to enable estimates of cross-cohort differences while controlling for age-related factors. Regression analyses were used to compute risk for alcohol dependence associated with birth cohort membership, before and after inclusion of AOD as a covariate.Results: Both men and women born between 1944 and 1963 had earlier ages of onset for drinking than did the earliest birth cohort analyzed (1934-43). However, the net decrease in AOD was twice as large for women (3.2 years) than that for men (1.6 years). After adjusting for AOD, differences in lifetime prevalence between different birth cohorts of women were rendered nonsignificant, indicating that AOD accounts for a Substantial portion of change in the lifetime prevalence of alcohol dependence.Conclusions: These results suggest that a decrease in AOD accounts for much of the increase in lifetime alcohol dependence among women. AOD is likely to be an indicator of dynamic, and therefore modifiable risk behaviors impacting risk for alcohol dependence.