Angiogenesis in human coronary atherosclerotic plaques.
Angiogenesis in human coronary atherosclerotic plaques.
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发表时间：
1994-10
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通讯作者：
E. O’Brien;M. Garvin;R. Dev;D. Stewart;T. Hinohara;J. Simpson;S. Schwartz
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作者：
E. O’Brien;M. Garvin;R. Dev;D. Stewart;T. Hinohara;J. Simpson;S. Schwartz
冠状动脉壁的新生血管形成与动脉粥样硬化斑块的存在有关。这些斑块内微血管形成的机制尚不清楚。本研究的目的是检查斑块微血管中内皮细胞复制的流行率。分析了201例原发性和再狭窄冠状动脉粥样硬化斑块切除术标本的微血管和增殖情况，分别通过阳性免疫标记Ulex凝集素和增殖细胞核抗原反映。在原发性而非再狭窄标本中，任何细胞类型的增殖均与同一载玻片上的微血管检测相关。然而，斑块内微血管在再狭窄中比原发标本更常见（P = 0.004）。十二个高度血管化的标本复制的证据进行了详细的组织形态学和定量图像分析。在200 x下，识别出每个载玻片的最血管光学视野，并且始终包括斑块巨噬细胞。这些标本的总载玻片内皮细胞复制指数各不相同，但在某些情况下显著升高（例如，43.5%）。斑块内血管生成的作用可能类似于肿瘤或伤口血管生成，并且在冠状动脉病变和再狭窄的发展和进展中是重要的。
Neovascularization in the walls of coronary arteries is associated with the presence of atherosclerotic plaque. The mechanisms responsible for the formation of these intraplaque microvessels are not understood. The purpose of this study is to examine the prevalence of endothelial cell replication in plaque microvessels. Two hundred and one primary and restenotic coronary atherectomy specimens were analyzed for the presence of microvessels and proliferation as reflected by positive immunolabeling for Ulex agglutinin and the proliferating cell nuclear antigen, respectively. In primary but not restenotic specimens, proliferation of any cell type was associated with the detection of microvessels on the same slide. However, intraplaque microvessels were more commonly found in restenotic compared to primary specimens (P = 0.004). Twelve highly vascularized specimens with evidence of replication were subjected to detailed histomorphological and quantitative image analyses. At 200 x, the most vascular optical field of each slide was identified and consistently included plaque macrophages. Total slide endothelial cell replication indices for these specimens varied, but in some instances were remarkably elevated (eg, 43.5%). The role of intraplaque angiogenesis may be analogous to that of tumor or wound angiogenesis and be important in development and progression of coronary artery lesions and restenosis.