Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis.
Differential expression of substance P receptors in patients with Crohn's disease and ulcerative colitis.
复制标题
克罗恩病和溃疡性结肠炎患者 P 物质受体的差异表达。
DOI：
10.1016/0016-5085(95)90394-1
复制
发表时间：
1995
期刊：
影响因子：
29.4
通讯作者：
Pappas,TN
中科院分区：
文献类型：
--
作者：
Mantyh,CR;Vigna,SR;Bollinger,RR;Mantyh,PW;Maggio,JE;Pappas,TN
背景与目的虽然克罗恩病（CD）和溃疡性结肠炎（UC）在临床和病理上存在差异，但往往缺乏区别特征，使得诊断和治疗存在问题。本研究评价了CD和UC患者P物质（SP）受体表达的差异。Methodstissue samples from patients with inflammatory bowel disease or control patients were obtained at surgery，processed for 125 I-SP binding，and analyzed by quantitative autoradiography.ResultsPatients with CD showed massive increase in SP receptor in lymphoid aggregates，small vessels，以及小肠和大肠的肠神经元。16例CD标本中有6例没有CD的病理学证据，但继续表达高浓度的SP受体。病理学阳性的UC患者结肠淋巴聚集体和小血管上显示高浓度的SP受体，但肠神经元上没有。没有增加SP结合是明显的临床和病理学静止UC结肠和正常的UC回肠stomach samples.ConclusionsThe增加SP受体的表达CD患者的肠神经元区分CD从UC。病理正常CD组织中持续增加的SP结合可能表明亚临床疾病状态。SP受体表达在炎症性肠病的诊断、病因学和治疗中可能具有重要意义。
Background & AimsAlthough clinical and pathological differences exist between Crohn's disease (CD) and ulcerative colitis (UC), distinguishing features are often absent, making diagnosis and treatment problematic. This study evaluated the differences in the expression of substance P (SP) receptors in patients with CD or UC.MethodsTissue samples from patients with inflammatory bowel disease or control patients were obtained at surgery, processed for125I-SP binding, and analyzed by quantitative autoradiography.ResultsPatients with CD showed a massive increase in SP receptors in lymphoid aggregates, small blood vessels, and enteric neurons of the small and large bowel relative to controls. Six of 16 CD specimens had no pathological evidence of CD yet continued to express high concentrations of SP receptors. Pathologically positive patients with UC showed high concentrations of SP receptors on colonic lymphoid aggregates and small blood vessels but not enteric neurons. No increased SP binding was evident in clinically and pathologically quiescent UC colons and normal UC ileostomy samples.ConclusionsThe increased expression of SP receptors on the enteric neurons of patients with CD distinguishes CD from UC. The persistent increased SP binding in pathologically normal CD tissue may indicate a subclinical disease state. SP receptor expression may have important diagnostic, etiologic, and therapeutic usefulness in inflammatory bowel disease.