Influenza virus-induced lung injury: pathogenesis and implications for treatment
Influenza virus-induced lung injury: pathogenesis and implications for treatment
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DOI：
10.1183/09031936.00186214
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发表时间：
2015-05-01
影响因子：
24.3
通讯作者：
Budinger, G. R. Scott
中科院分区：
文献类型：
--
作者：
Herold, Susanne;Becker, Christin;Budinger, G. R. Scott
流感病毒是人类最重要的病原体之一，引起大量的季节性和大流行性发病率和死亡率。在人类中，下呼吸道感染可导致肺泡腔室充血、急性呼吸窘迫综合征的发展和呼吸衰竭的死亡。流感介导的气道、肺泡上皮和肺泡内皮的损伤由以下因素的组合引起：1）固有的病毒致病性，归因于其对宿主气道和肺泡上皮细胞的嗜性;和2）强大的宿主先天免疫应答，其在促进病毒清除的同时，可使肺损伤的严重程度恶化。在这篇综述中，我们总结了流感病毒感染过程中病毒宿主界面的分子事件，突出了一些重要的细胞反应。我们讨论了免疫介导的病毒清除，促进或维持肺损伤的机制，流感诱导损伤后的肺再生，以及流感预防和治疗的最新进展。
The influenza viruses are some of the Most important human pathogens, causing substantial seasonal and pandemic morbidity and mortality. In humans, infection of the lower respiratory tract of can result in flooding of the alveolar compartment, development of acute respiratory distress syndrome and death from respiratory failure. Influenza-mediated damage of the airway, alveolar epithelium and alveolar endothelium results from a combination of: 1) intrinsic viral pathogenicity, attributable to its tropism for host airway and alveolar epithelial cells; and 2) a robust host innate immune response, which, while contributing to viral clearance, can worsen the severity of lung injury. In this review, we summarise the molecular events at the virus host interface during influenza virus infection, highlighting some of the important cellular responses. We discuss immune-mediated viral clearance, the mechanisms promoting or perpetuating lung injury, lung regeneration after influenza-induced injury, and recent advances in influenza prevention and therapy.