Cardiovascular risk factors and venous thromboembolism incidence - The longitudinal investigation of thromboembolism etiology
Cardiovascular risk factors and venous thromboembolism incidence - The longitudinal investigation of thromboembolism etiology
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DOI：
10.1001/archinte.162.10.1182
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发表时间：
2002-05-27
影响因子：
--
通讯作者：
Folsom, AR
中科院分区：
文献类型：
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作者：
Tsai, AW;Cushman, M;Folsom, AR
背景资料：传统的心血管危险因素和静脉血栓栓塞症（VTE）风险之间的关系在前瞻性研究中尚未得到广泛的研究。方法：为了确定动脉粥样硬化危险因素是否也与VTE发病率增加有关，我们对1987年至1998年美国6个社区的19293名既往无VTE的男性和女性进行了前瞻性研究。结果：在中位随访8年期间，有215例经验证的VTE事件（1.45/1000人-年）。年龄校正的风险比为1.4（95%置信区间[CI]，1.1-1.9），男性与女性，1.6（95% CI，1.2-2.2），黑人与白人，1.7（95% CI，1.5-2.0）每10岁，吸烟，高血压，血脂异常，缺乏体力活动和饮酒与VTE的风险无关。年龄、种族和性别校正的体重指数类别（计算为体重（千克）除以身高（米）的平方）小于23、25至小于30、30至小于35、35至小于40和40或以上的风险比分别为1.0、1.5、2.2、1.5和2.7（P <0.05）。
Background: The association between traditional cardiovascular risk factors and risk of venous thromboembolism (VTE) has not been extensively examined in prospective studies.Methods: To deter-mine whether atherosclerotic risk factors are also associated with increased incidence of VTE, we conducted a prospective study of 19293 men and women without previous VTE in 6 US communities between 1987 and 1998.Results: There were 215 validated VTE events (1.45 per 1000 person-years) during a median of 8 years of follow-up. The age-adjusted hazard ratio was 1.4 (95% confidence interval [CI], 1.1-1.9) for men vs women, 1.6 (95% CI, 1.2-2.2) for blacks vs whites, and 1.7 (95% CI, 1.5-2.0) per decade of age, Cigarette smoking, hypertension, dyslipidemia, physical inactivity, and alcohol consumption were not associated with risk of VTE. Age-, race-, and sex-adjusted hazard ratios for body mass index categories (calculated as the weight in kilograms divided by the height in meters squared) of less than 23, 25 to less than 30, 30 to less than 35, 35 to less than 40, and 40 or more were 1.0, 1.5, 2.2, 1.5, and 2.7, respectively (P