Role of V1a vasopressin receptors in the control of aggression in Syrian hamsters
Role of V1a vasopressin receptors in the control of aggression in Syrian hamsters
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DOI：
10.1016/j.brainres.2005.12.081
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发表时间：
2006-02-16
期刊：
影响因子：
2.9
通讯作者：
Huhman, KL
中科院分区：
文献类型：
--
作者：
Albers, HE;Dean, A;Huhman, KL
本研究探讨了一种假说，即社会隔离通过增加下丘脑前部的加压素受体S的数目来增加攻击性。雄性仓鼠被随机分配到一组，每周与一只小的非攻击性仓鼠互动三次，持续3周(有社交经验的)，或被分配到一组不与其他仓鼠进行社交互动的组(社交隔离)。在实验的最后一天，两组仓鼠都被放在一个中立的场地上，有一个小的，非攻击性的入侵者，并对激励性行为进行10分钟的评分。在社交隔离中，攻击的持续时间和攻击次数明显高于社交经验丰富的仓鼠。在攻击开始的潜伏期、侧翼标记的数量或防御/顺从、社交或非社交行为的持续时间方面，组间没有显著差异。社交隔离仓鼠的AH、下丘脑室旁核和下丘脑外侧核的VIA受体结合量显著高于社交经验仓鼠。在社交经验丰富的仓鼠的中央杏仁核中，VIA受体结合量显著高于社交隔离仓鼠。在社交经验丰富的仓鼠中，血清中的睾酮浓度明显高于社交隔离仓鼠。这些数据支持这一假设，即社会孤立通过增加AH中的Via加压素受体的数量来增加攻击性。(C)2006爱思唯尔B.V.保留所有权利。
The present study investigated the hypothesis that social isolation increases aggression by increasing the number of Via vasopressin receptor s in the anterior hypothalamus (AH). Male hamsters were randomly assigned to a group that was allowed to interact with a small nonaggressive hamster three times each week for 3 weeks (socially experienced) or to a group that did not interact socially with other hamsters (social isolates). on the final day of the experiment, hamsters in both groups were placed in a neutral arena with a small, nonaggressive intruder, and agonistic behavior was scored for 10 min. In social isolates, the duration of aggression and the number of attacks were significantly greater than in socially experienced hamsters. There were no significant between-group differences in the latency to the onset of aggression, the number of flank marks or in the duration of defensive/ submissive, social or nonsocial behavior. The amount of Via receptor binding was significantly greater in the AH, the paraventricular nucleus of the hypothalamus and the lateral hypothalamus in the social isolates than in the socially experienced hamsters. The amount of Via receptor binding was significantly greater in the central amygdala of socially experienced hamsters than in socially isolated hamsters. Serum concentrations of testosterone were significantly higher in the socially experienced hamsters than in social isolates. These data support the hypothesis that social isolation increases aggression by increasing the number of Via vasopressin receptors in the AH. (c) 2006 Elsevier B.V. All rights reserved.