Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor
Benzothiazole Sulfinate: a Water-Soluble and Slow-Releasing Sulfur Dioxide Donor
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DOI：
10.1021/acschembio.6b00106
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发表时间：
2016-06-01
影响因子：
4
通讯作者：
Xian, Ming
中科院分区：
文献类型：
--
作者：
Day, Jacob J.;Yang, Zhenhua;Xian, Ming
Sulfur dioxide (SO2) has long -been considered a toxic environmental pollutant and byproduct of industrial processing. Recently become evident that SO2 may also havel:regUlatory functions in mammalian puh-uonary systems. Ho:IV-ever, the study of these effects has proven to be challenging due to the difficulty in administering SO2 in a tellable manner. In this work, we report the diicOvery of a new pH -dependent and watensbluble SO2 donor, benzothiazole sulfinate (BTS): We have found BTS to have slow:I:and sustained SO2 release at physiological pH. Additionally, we have explored its vasorelaxation properties as compated.to the -authentic SO2 gas solutions. The slow. release of BTS should make it.a useful toot for the study of endogenously generated SO2.
