Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix.
Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix.
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DOI：
10.1038/s41551-018-0191-4
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发表时间：
2018-03
影响因子：
28.1
通讯作者：
Wu JC
中科院分区：
文献类型：
--
作者：
Lee AS;Inayathullah M;Lijkwan MA;Zhao X;Sun W;Park S;Hong WX;Parekh MB;Malkovskiy AV;Lau E;Qin X;Pothineni VR;Sanchez-Freire V;Zhang WY;Kooreman NG;Ebert AD;Chan CKF;Nguyen PK;Rajadas J;Wu JC
基于干细胞的疗法为再生医学带来了相当大的希望。然而，细胞递送后数周内的急性供体细胞死亡仍然是临床转化的关键障碍。干细胞与促存活因子的共移植可以改善细胞植入，但是这种策略受到因子的典型短半衰期以及基质胶和其他未化学定义的支架的使用的阻碍。在这里，我们报告了一种与促生存肽类似物交联的胶原-树状聚合物生物材料，其粘附于细胞外基质并缓慢释放肽，显著延长了缺血性损伤小鼠模型中干细胞的存活。该生物材料可以作为一种通用的输送系统，以改善细胞替代治疗的功能结果。
Stem-cell-based therapies hold considerable promise for regenerative medicine. However, acute donor-cell death within several weeks after cell delivery remains a critical hurdle for clinical translation. Co-transplantation of stem cells with pro-survival factors can improve cell engraftment, but this strategy has been hampered by the typically short half-lives of the factors and by the use of Matrigel and other scaffolds that are not chemically defined. Here, we report a collagen–dendrimer biomaterial crosslinked with pro-survival peptide analogues that adheres to the extracellular matrix and slowly releases the peptides, significantly prolonging stem cell survival in mouse models of ischaemic injury. The biomaterial can serve as a generic delivery system to improve functional outcomes in cell-replacement therapy.
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影响因子：
24
作者：
Li, Zongjin;Lee, Andrew;Huang, Mei;Chun, Hyung;Chung, Jaehoon;Chu, Pauline;Hoyt, Grant;Yang, Phillip;Rosenberg, Jarrett;Robbins, Robert C.;Wu, Joseph C.
通讯作者：
Wu, Joseph C.
骨髓干细胞移植到缺血心肌后的体内功能和转录谱。
DOI：
10.1161/atvbaha.111.238618
发表时间：
2012-01
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Sheikh AY;Huber BC;Narsinh KH;Spin JM;van der Bogt K;de Almeida PE;Ransohoff KJ;Kraft DL;Fajardo G;Ardigo D;Ransohoff J;Bernstein D;Fischbein MP;Robbins RC;Wu JC
通讯作者：
Wu JC
影响因子：
37.8
作者：
Cao, F;Lin, S;Wu, JC
通讯作者：
Wu, JC
影响因子：
5.2
作者：
Simpson, David;Liu, Hong;Dudley, Samuel C., Jr.
通讯作者：
Dudley, Samuel C., Jr.
影响因子：
41.2
作者：
Dave, P. C.;Dingal, P.;Discher, Dennis E.
通讯作者：
Discher, Dennis E.