Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot
Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot
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DOI：
10.1152/ajpheart.00679.2011
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发表时间：
2012-03-01
影响因子：
4.8
通讯作者：
Kassab, Ghassan
中科院分区：
文献类型：
--
作者：
Zhong, Liang;Gobeawan, Like;Kassab, Ghassan
钟丽，高贝万，苏勇，谭建林，Ghista D, chut，谭瑞麟，Kassab G.修复后法洛四联症患者右心室壁弯曲度和面积应变。[J]中国生物医学工程学报，2016,31(2):444 - 444。首次发表于2011年12月30日；doi: 10.1152 / ajpheart.00679.2011。定量了解修复性法洛四联症（rTOF）患者右心室（RV）重构对患者管理至关重要。本研究的目的是利用心脏磁共振成像（MRI）对右心室进行三维（3-D）重建，量化区域曲率和区域应变。14例rTOF患者和9例正常受试者进行了心脏MRI扫描。三维右心室心内膜表面模型由人工绘制的轮廓重建，并确定舒张末期（ED）和收缩末期（ES）之间的对应关系。计算了ED和ES处的区域曲率(C)和表面积以及区域应变。rTOF患者的右心室形状和变形在几个方面与正常人不同。首先，ED处的弯曲度(13个段的平均值，0.030 +/- 0.0076 vs. 0.029 +/- 0.0065 mm(-1)；P < 0.05)和ES(13个节段的平均值，0.040 +/- 0.012 vs. 0.034 +/- 0.0072 mm(-1)；P < 0.001)，慢性肺反流降低。其次，ED处的表面积显著增加（13个节段的平均值，982 +/- 192 vs. 1397 +/- 387 mm）；P < 0.001)和ES(13个节段的平均值，576 +/- 130对1,012 +/- 302 mm(2)；P < 0.001)。特别是，rTOF患者的游离壁表面积明显大于正常受试者，而室间隔壁的表面积则不明显。第三，rTOF患者的区域应变显著降低（13个节段的平均值，56 +/- 6比34 +/- 7%，P < 0.0001）。第四，ED的表面积增加（5,726 +/- 969 vs. 6,605 +/- 1,122 mm）；P < 0.05)和ES (4,280 +/- 758 vs. 5,569 +/- 1,112 mm)；右心室流出道面积应变降低（29 +/- 8% vs. 18 +/- 8%; P < 0.001）。这些发现表明，在rTOF和正常受试者之间存在显著的几何和应变差异，这可能有助于指导治疗。
Zhong L, Gobeawan L, Su Y, Tan JL, Ghista D, Chua T, Tan RS, Kassab G. Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot. Am J Physiol Heart Circ Physiol 302: H1306-H1316, 2012. First published December 30, 2011; doi:10.1152/ajpheart.00679.2011.-A quantitative understanding of right ventricular (RV) remodeling in repaired tetralogy of Fallot (rTOF) is crucial for patient management. The objective of this study is to quantify the regional curvatures and area strain based on three-dimensional (3-D) reconstructions of the RV using cardiac magnetic resonance imaging (MRI). Fourteen (14) rTOF patients and nine (9) normal subjects underwent cardiac MRI scan. 3-D RV endocardial surface models were reconstructed from manually delineated contours and correspondence between end-diastole (ED) and end systole (ES) was determined. Regional curvedness (C) and surface area at ED and ES were calculated as well as the area strain. The RV shape and deformation in rTOF patients differed from normal subjects in several respects. Firstly, the curvedness at ED (mean for 13 segments, 0.030 +/- 0.0076 vs. 0.029 +/- 0.0065 mm(-1); P < 0.05) and ES (mean for 13 segments, 0.040 +/- 0.012 vs. 0.034 +/- 0.0072 mm(-1); P < 0.001) was decreased by chronic pulmonary regurgitation. Secondly, the surface area increased significantly at ED (mean for 13 segments, 982 +/- 192 vs. 1,397 +/- 387 mm(2); P < 0.001) and ES (mean for 13 segments, 576 +/- 130 vs. 1,012 +/- 302 mm(2); P < 0.001). In particular, rTOF patients had significantly larger surface area than that in normal subjects in the free wall but not for the septal wall. Thirdly, area strain was significantly decreased (mean for 13 segments, 56 +/- 6 vs. 34 +/- 7%; P < 0.0001) in rTOF patients. Fourthly, there were increases in surface area at ED (5,726 +/- 969 vs. 6,605 +/- 1,122 mm(2); P < 0.05) and ES (4,280 +/- 758 vs. 5,569 +/- 1,112 mm(2); P < 0.01) and decrease in area strain (29 +/- 8 vs. 18 +/- 8%; P < 0.001) for RV outflow tract. These findings suggest significant geometric and strain differences between rTOF and normal subjects that may help guide therapeutic treatment.