Inhibiting the inhibitors: evaluating agents targeting cancer immunosuppression.
Inhibiting the inhibitors: evaluating agents targeting cancer immunosuppression.
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DOI：
10.1517/14712598.2010.482207
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发表时间：
2010-07
影响因子：
4.6
通讯作者：
Whiteside TL
中科院分区：
文献类型：
--
作者：
Whiteside TL
癌症的免疫治疗并没有改善无病生存或总体患者生存。癌症免疫治疗试验中免疫学和临床反应之间缺乏一致性被认为是由于肿瘤驱动的免疫抑制的普遍存在，使得肿瘤逃逸，并且目前的治疗方法没有充分靶向。由于肿瘤诱导的抑制的多种机制现已被确定并显示有助于肿瘤逃逸，因此出现了干扰这些机制的机会。一系列已知的肿瘤衍生抑制剂（酶、受体、配体、微泡和可溶性因子）现在可以被生物或代谢剂阻断或中和。这些药物单独使用或相互联合使用或与常规癌症治疗联合使用，为控制肿瘤逃逸提供了新的治疗策略。本文综述了目前可用于对抗肿瘤免疫逃逸的抑制剂。在癌症患者中恢复有效的抗肿瘤免疫将需要新的方法，其目的在于：（a）保护免疫细胞免受髓源性抑制细胞（MDSC）、调节性T细胞（Treg）或抑制因子的不利影响，从而增强效应子功能，和（B）延长中枢记忆T细胞的存活，从而确保长期保护。肿瘤逃逸机制的抑制剂可以恢复癌症患者的抗肿瘤免疫应答。
Immunotherapy of cancer has not improved disease-free or overall patient survival. The lack of concordance between immunologic and clinical responses in cancer immunotherapy trials is thought to result from the pervasive presence of tumor-driven immune suppression that allows tumor to escape and that has not been adequately targeted by current therapies. Because multiple mechanisms of tumor induced suppression have now been identified and shown to contribute to tumor escape, the opportunity arises to interfere with these mechanisms. A range of known tumor-derived inhibitors (enzymes, receptors, ligands, microvesicles and soluble factors) can now be blocked or neutralized by biologic or metabolic agents. Used alone or in combination with each other or with conventional cancer therapies, these agents offer novel therapeutic strategies for the control of tumor escape. This review deals with currently available inhibitors for counteracting tumor immune escape. The restoration of effective anti-tumor immunity in patients with cancer will require new approaches aiming at: (a) protection of immune cells from adverse effects of myeloid-derived suppressor cells (MDSC), regulatory T cells (Treg) or inhibitory factors thus enhancing effector functions, and (b) prolong survival of central memory T cells thus ensuring long-term protection. Inhibitors of mechanisms responsible for tumor escape could restore anti-tumor immune responses in patients with cancer.
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影响因子：
11.2
作者：
Dieli F;Vermijlen D;Fulfaro F;Caccamo N;Meraviglia S;Cicero G;Roberts A;Buccheri S;D'Asaro M;Gebbia N;Salerno A;Eberl M;Hayday AC
通讯作者：
Hayday AC
影响因子：
5.5
作者：
Campoli, M;Chang, CC;Ferrone, S
通讯作者：
Ferrone, S
DOI：
10.1073/pnas.0905139106
发表时间：
2009-12-01
影响因子：
11.1
作者：
Bogunovic, Dusan;O'Neill, David W.;Bhardwaj, Nina
通讯作者：
Bhardwaj, Nina
影响因子：
15.9
作者：
Charles, Kellie A.;Kulbe, Hagen;Hagemann, Thorsten
通讯作者：
Hagemann, Thorsten
影响因子：
5.4
作者：
Caserta, Stefano;Alessi, Patrizia;Mondino, Anna
通讯作者：
Mondino, Anna