Template images for nonhuman primate neuroimaging: 1. Baboon
Template images for nonhuman primate neuroimaging: 1. Baboon
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DOI：
10.1006/nimg.2001.0752
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发表时间：
2001-09-01
期刊：
影响因子：
5.7
通讯作者：
Perlmutter, JS
中科院分区：
文献类型：
--
作者：
Black, KJ;Snyder, AZ;Perlmutter, JS
许多受试者的功能性大脑图像的共同配准提供了多种实验优势，并广泛用于人类研究。基于体素的配准方法需要高质量的 3D 模板图像，最好是与已发布的图集相对应的图像。模板图像可用于人类，但我们无法找到适合狒狒神经影像研究的模板。在这里，我们描述了分别来自 9 只和 7 只狒狒的 T1 加权结构 MR 模板图像和 PET 血流模板的形成。定制软件将单个 MR 图像与 MRI 模板对齐；仅在初步估计任何严重的旋转不对中时才需要人工监督。在这些对齐的单个图像中，内部皮质下基准点与显微摄影狒狒图集密切对应，平均误差为 1.53 毫米。与每个点的平均位置相比，皮质测试点的平均误差为 1.99 分钟。将单个 PET 血流图像直接与 PET 模板对齐与通过每个受试者的 MR 图像进行的两步对齐过程进行比较。两个变换在 0.41 毫米、0.54 度和 1.0% 范围内相同（平移、旋转和线性拉伸；平均值）。这些数量可以检查对准软件以及模板图像的有效性。狒狒结构 AIR 和血流 PET 模板可在 Internet (purl.org/net/kbmd/b2k) 上获取，并且可用作任何图像配准软件的目标。 (C) 2001 年学术出版社。
Coregistration of functional brain images across many subjects offers several experimental advantages and is widely used for studies in humans. Voxel-based coregistration methods require a high-quality 3-D template image, preferably one that corresponds to a published atlas. Template images are available for human, but we could not find an appropriate template for neuroimaging studies in baboon. Here we describe the formation of a T1-weighted structural MR template image and a PET blood flow template, derived from 9 and 7 baboons, respectively. Custom software aligns individual MR images to the MRI template; human supervision is needed only to initially estimate any gross rotational misalignment. In these aligned individual images, internal subcortical fiducial points correspond closely to a photomicrographic baboon atlas with an average error of 1.53 mm. Cortical test points showed a mean error of 1.99 min compared to the mean location for each point. Alignment of individual PET blood flow images directly to the PET template was compared to a two-step alignment process via each subject's MR image. The two transformations were identical within 0.41 mm, 0.54 degrees, and 1.0% (translation, rotation, and linear stretch; mean). These quantities provide a check on the validity of the alignment software as well as of the template images. The baboon structural AIR and blood flow PET templates are available on the Internet (purl.org/net/kbmd/b2k) and can be used as targets for any image registration software. (C) 2001 Academic Press.