Osteopontin and interleukin-8 expression is independently associated with prostate cancer recurrence.
Osteopontin and interleukin-8 expression is independently associated with prostate cancer recurrence.
复制标题
DOI：
10.1158/1078-0432.ccr-08-0738
复制
发表时间：
2008-07-01
期刊：
影响因子：
--
通讯作者：
Lokeshwar BL
中科院分区：
文献类型：
--
作者：
Caruso DJ;Carmack AJ;Lokeshwar VB;Duncan RC;Soloway MS;Lokeshwar BL
缺乏可靠的生物标志物限制了前列腺癌(CAP)PSA生化复发(疾病进展)的准确预测。骨桥蛋白(OPN)和白介素8(IL-8)这两种炎性趋化因子与肿瘤血管生成和转移密切相关。我们调查了OPN和IL-8在CAP中的表达是否与疾病进展有关。103例前列腺切除标本取自至少72个月随访的患者。免疫组织化学方法检测OPN和IL-8的表达，并对表达强度和面积进行分级。用单因素和多因素模型分析OPN和IL-8染色与生化复发的关系。在肿瘤细胞中，复发组骨桥蛋白和IL-8染色(203.2±78.4；181.1±89.3)高于未复发组(122.7±76.6；96.4±85.6；p<；0.001)。复发组瘤旁良性区域的OPN和IL-8表达也明显高于未复发组。单因素分析显示，除年龄外，所有术前、术后指标及OPN和IL-8染色评分与生化复发显著相关(P<；0.05)。在多变量分析中，边缘状态和OPN染色独立地与72个月内的生化复发相关。OPN单独或联合IL-8和精囊侵袭是预测24个月内生化复发的重要指标。OPN和IL-8染色预测复发具有较高的敏感性(75.5%，73.6%)和特异性(76%，70.6%)。在前列腺切除标本中，OPN的表达与生化复发独立相关。OPN和IL-8都可能是早期疾病进展的预测因子。
Lack of reliable biomarkers limits accurate prediction of PSA biochemical recurrence (disease progression) in prostate cancer (CaP). The two inflammatory chemokines, Osteopontin (OPN) and interleukin-8 (IL-8) are associated with tumor angiogenesis and metastasis. We investigated whether OPN and IL-8 expression in CaP correlates with disease progression. Archival prostatectomy specimens (n = 103) were obtained from patients with minimum 72 month follow-up. OPN and IL-8 expression was evaluated by immunohistochemistry and graded for intensity and the area. Association of OPN and IL-8 staining with biochemical recurrence was evaluated by univariate and multivariate models. In tumor cells, OPN and IL-8 staining was higher in the recurred group (203.2 ± 78.4; 181.1 ± 89.3) than in the non-recurred group (122.7 ± 76.6; 96.4 ± 85.6; p < 0.001). Higher OPN and IL-8 staining was also observed in benign areas adjacent to tumor in the recurred group, than in non-recurred group. In univariate analysis, except age, all pre- and post-operative parameters and OPN and IL-8 staining scores significantly associated with biochemical recurrence (P < 0.05). In multivariate analysis, margin status and OPN staining independently associated with biochemical recurrence within 72 months. OPN, either alone or with IL-8 and seminal vesicle invasion was a significant parameter in predicting biochemical recurrence within 24 months. OPN and IL-8 staining predicted recurrence with high sensitivity (75.5% 73.6%) and specificity (76%, 70.6%). In prostatectomy specimens, OPN expression is independently associated with biochemical recurrence. Both OPN and IL-8 may be predictors of early disease progression.