Additive effect of plant sterol-ester margarine and cerivastatin in lowering low-density lipoprotein cholesterol in primary hypercholesterolemia
Additive effect of plant sterol-ester margarine and cerivastatin in lowering low-density lipoprotein cholesterol in primary hypercholesterolemia
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DOI：
10.1016/s0002-9149(02)02600-0
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发表时间：
2002-10-01
影响因子：
2.8
通讯作者：
Simons, LA
中科院分区：
文献类型：
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作者：
Simons, LA
本研究的目的是评估植物甾醇酯人造黄油与他汀类药物联合摄入时对低密度脂蛋白（LDL）胆固醇降低是否具有相加或交互作用。这是一项多中心、随机、双盲研究，采用平衡2 x 2析因设计，包含4个平行治疗组。这4种每日治疗方案为：（1）安慰剂加常规人造黄油25 g（n = 38）;（2）安慰剂加甾醇酯人造黄油25 g（2 g植物甾醇）（n = 39）;（3）西立伐他汀400 mug加常规人造黄油25 g（n = 38）;（4）西立伐他汀400 mug加甾醇酯人造黄油25 g（n = 37）。这项研究在患有原发性高胆固醇血症的男性和女性中进行，基线LDL胆固醇大于或等于97 mg/dl（平均206）。主要疗效参数是基线和4周治疗结束时LDL胆固醇的百分比变化。西立伐他汀（与安慰剂相比）降低LDL胆固醇32%（95%置信区间28%至36%，p
The objective of this study was to evaluate whether plant sterol-ester margarine has an additive or interactive effect on low-density lipoprotein (LDL) cholesterol reduction when ingested in combination with a statin drug. This was a multicenter, randomized, double-blind study with 4 parallel treatment arms in a balanced 2 x 2 factorial design. The, 4 daily treatment options were: (1) placebo plus regular margarine 25 g (n = 38); (2) placebo plus sterol-ester margarine 25 g (2 g of plant sterol) (n = 39); (3) cerivastatin 400 mug plus regular margarine 25 g (n = 38); and (4) cerivastatin 400 mug plus sterol-ester margarine 25 g (n = 37). The study was conducted in men and women with primary hypercholesterolemia with baseline LDL cholesterol greater than or equal to97 mg/dl (mean 206). The primary efficacy parameter was the percent change in LDL cholesterol between baseline and at the end of 4 weeks' treatment. Cerivastatin (vs placebo) reduced LDL cholesterol by 32% (95% confidence intervals 28% to 36%, p