Untangling the relationship between microglia and tau in Alzheimer's disease.
Untangling the relationship between microglia and tau in Alzheimer's disease.
复制标题
解开阿尔茨海默病中小胶质细胞和 tau 蛋白之间的关系。
DOI：
10.1016/j.tins.2021.10.002
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发表时间：
2021
影响因子：
15.9
通讯作者：
Kreisl,WilliamCharles
中科院分区：
文献类型：
--
作者：
Rossano,SamanthaM;Kreisl,WilliamCharles
尸检和成像研究已经证明了阿尔茨海默病（AD）中tau蛋白进展的典型模式，在“Braak”阶段的解剖序列中扩散到以前未受影响的区域。在最近的一项研究中，Pascoal等人提供的证据表明，小胶质细胞增生与tau蛋白以Braak样模式共定位，进一步证实了小胶质细胞活化与缠结病理学的传播密切相关的观点。
Autopsy and imaging studies have demonstrated a typical pattern of tau progression in Alzheimer's disease (AD), spreading to previously unaffected regions in an anatomical sequence of ‘Braak' stages. In a recent study, Pascoal et al. provide evidence that microgliosis colocalizes with tau in a Braak-like pattern, furthering the notion that microglial activation is strongly related to the propagation of tangle pathology.