A meta-analysis of the impact of pre-existing and new-onset atrial fibrillation on clinical outcomes in patients undergoing transcatheter aortic valve implantation
A meta-analysis of the impact of pre-existing and new-onset atrial fibrillation on clinical outcomes in patients undergoing transcatheter aortic valve implantation
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DOI：
10.4244/eijy15m11_12
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发表时间：
2016-10-01
期刊：
影响因子：
6.2
通讯作者：
Esposito, Giovanni
中科院分区：
文献类型：
--
作者：
Sannino, Anna;Gargiulo, Giuseppe;Esposito, Giovanni
目的：关于既存房颤（AF）和新发房颤（NOAF）在经导管主动脉瓣植入术（TAVI）中的预后作用知之甚少。因此，本荟萃分析的目的是比较接受TAVI的患者（有和无既存和新发AF）的短期和长期临床结局。方法和结果：对26项研究的早期和长期全因死亡率进行了分析，这些研究招募了14，078名接受TAVI的患者，其中33.4%患有既存AF，17.5%患有NOAF，心血管死亡率和脑血管事件（CVE）。在既存AF患者中，30天全因死亡率与窦性心律（SR）患者相似。相反，既存AF患者的长期全因和心血管死亡率显著高于SR患者（20项研究; 8，743例患者; HR：1.68; p
Aims: Little is known about the prognostic role of pre-existing atrial fibrillation (AF) and new-onset AF (NOAF) in transcatheter aortic valve implantation (TAVI). Therefore, the aim of this meta-analysis was to compare the short-and long-term clinical outcomes of patients undergoing TAVI with and without preexisting and new-onset AF.Methods and results: Twenty-six studies, enrolling 14,078 patients undergoing TAVI, of whom 33.4% had pre-existing AF and 17.5% had NOAF, were analysed for early and long-term all-cause mortality, cardiovascular mortality and cerebrovascular events (CVE). In patients with pre-existing AF, 30-day all-cause mortality was similar to patients in sinus rhythm (SR). Conversely, long-term all-cause and cardiovascular mortality were significantly greater in pre- existing AF patients than in patients with SR (20 studies; 8,743 patients; HR: 1.68; p