Perfluorinated Alkyl Acids in Blood Serum from Primiparous Women in Sweden: Serial Sampling during Pregnancy and Nursing, And Temporal Trends 1996-2010
Perfluorinated Alkyl Acids in Blood Serum from Primiparous Women in Sweden: Serial Sampling during Pregnancy and Nursing, And Temporal Trends 1996-2010
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DOI：
10.1021/es301168c
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发表时间：
2012-08-21
影响因子：
11.4
通讯作者：
Darnerud, Per Ola
中科院分区：
文献类型：
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作者：
Glynn, Anders;Berger, Urs;Darnerud, Per Ola
我们调查了1996-2010年瑞典乌普萨拉县（N = 413）分娩后3周抽取的13种全氟烷基酸（PFAAs）和全氟辛烷磺酰胺（FOSA）的血清水平的时间趋势。短链全氟丁烷磺酸（PFBS）和全氟己烷磺酸（PFHxS）的水平分别增长了11%/年和8.3%/年，长链全氟壬酸盐（PFNA）和全氟癸酸盐（PFDA）的水平分别增长了4.3%/年和3.8%/年。与此同时，FOSA（22%/年）、全氟辛烷磺酸（PFOS， 8.4%/年）、全氟癸烷磺酸（PFDS， 10%/年）和全氟辛酸（PFOA， 3.1%/年）的水平也有所下降。因此，一种或几种暴露于后一种化合物的来源已经减少或消除，而暴露于前一种化合物的来源最近有所增加。我们利用包括脐带血（N = 19）在内的一系列母体血清样本，探讨了哺乳早期母体PFOS、PFOA和PFNA水平是否具有胎儿发育时期的代表性。妊娠期、哺乳期母体血清及脐带血PFAA水平呈显著相关性。脐带血水平与母体水平之间的相关性在分娩前不久或分娩后采集的母体血清中最为明显（PFOS和PFOA的r = 0.70-0.89）。在PFNA中也观察到类似的模式，尽管由于在脐带血中接近方法检测极限的水平，相关性不那么强。
We investigated temporal trends of blood serum levels of 13 perfluorinated alkyl acids (PFAAs) and perfluorooctane sulfonamide (FOSA) in primiparous women (N = 413) from Uppsala County, Sweden, sampled 3 weeks after delivery 1996-2010. Levels of the short-chain perfluorobutane sulfonate (PFBS) and perfluorohexane sulfonate (PFHxS) increased 11%/y and 8.3%/y, respectively, and levels of the long-chain perfluorononanoate (PFNA) and perfluorodecanoate (PFDA) increased 4.3%/y and 3.8%/y, respectively. Concomitantly, levels of FOSA (22%/y), perfluorooctane sulfonate (PFOS, 8.4%/y), perfluorodecane sulfonate (PFDS, 10%/y), and perfluorooctanoate (PFOA, 3.1%/y) decreased. Thus, one or several sources of exposure to the latter compounds have been reduced or eliminated, whereas exposure to the former compounds has recently increased. We explored if maternal levels of PFOS, PFOA, and PFNA during the early nursing period are representative for the fetal development period, using serial maternal serum samples, including cord blood (N = 19). PFAA levels in maternal serum sampled during pregnancy and the nursing period as well as in cord blood were strongly correlated. Strongest correlations between cord blood levels and maternal levels were observed for maternal serum sampled shortly before or after the delivery (r = 0.70-0.89 for PFOS and PFOA). A similar pattern was observed for PFNA, although the correlations were less strong due to levels close to the method detection limit in cord blood.