Salmonella secretion systems: Differential roles in pathogen-host interactions
Salmonella secretion systems: Differential roles in pathogen-host interactions
复制标题
沙门氏菌分泌系统：病原体与宿主相互作用中的不同作用
DOI：
10.1016/j.micres.2020.126591
复制
发表时间：
2020-12-01
影响因子：
6.7
通讯作者：
Liu, Shu-Lin
中科院分区：
文献类型：
--
作者：
Bao, Hongxia;Wang, Shuang;Liu, Shu-Lin
细菌属沙门氏菌包括大量食物传播病原体，这些病原体会引起宿主中各种胃肠道或全身性疾病。沙门氏菌使用多种分泌装置注入靶向真核宿主或细菌的各种效应子。在过去的几年中，在理解沙门氏菌分泌系统的结构特征和分子机制方面取得了长足的进步，尤其是关于它们在宿主 - 病原体相互作用中的作用。在这篇综述中，我们总结了沙门氏菌分泌系统的主要特征的当前进步。阐明分泌系统在感染各种宿主过程中的作用将扩大我们对微生物相互作用在维持人类健康中的重要性的理解，并将为开发新型治疗方法提供信息。
The bacterial genus Salmonella includes a large group of food-borne pathogens that cause a variety of gastro-intestinal or systemic diseases in hosts. Salmonella use several secretion devices to inject various effectors targeting eukaryotic hosts, or bacteria. In the past few years, considerable progress has been made towards understanding the structural features and molecular mechanisms of the secretion systems of Salmonella, particularly regarding their roles in host-pathogen interactions. In this review, we summarize the current advances about the main characteristics of the Salmonella secretion systems. Clarifying the roles of the secretion systems in the process of infecting various hosts will broaden our understanding of the importance of microbial interactions in maintaining human health and will provide information for developing novel therapeutic approaches.