Antifungal metabolites from the rhizospheric Penicillium sp YIM PH 30003 associated with Panax notoginseng
Antifungal metabolites from the rhizospheric Penicillium sp YIM PH 30003 associated with Panax notoginseng
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DOI：
10.1016/j.phytol.2015.01.010
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发表时间：
2015-03-01
影响因子：
1.7
通讯作者：
Ding, Zhongtao
中科院分区：
文献类型：
--
作者：
Yang, Yabin;Yang, Fangfang;Ding, Zhongtao
在三七内生真菌Penicillium sp. YIM PH30003的发酵过程中，分离到了两个新的n -苯甲酰氨基酸，peniginseng A-B（1-2）和两个新的脂肪酸，peniciginseng A-B（5-6）。F.H.陈。它们的结构是基于1D和2D核磁共振和质谱数据的组合来分配的。n -苯甲酰氨基酸（1-4）可能与罕见的铁载体雌蕊素具有相似的生物合成途径。化合物1 ~ 10对三七病原菌茄枯菌（Fusarium solani）具有一定的抑制活性（mic值为16 ~ 128 μ g/mL）。(C) 2015年欧洲植物化学学会。Elsevier B.V.版权所有。
Two new N-benzoylamino acids, peniginseng A-B (1-2), and two new fatty acids, peniciginseng A-B (5-6), were isolated during the fermentation of Penicillium sp. YIM PH30003, an endophytic fungus associated with Panax notoginseng (Burk.) F.H. Chen. Their structures were assigned based on a combination of 1D and 2D NMR and mass spectral data. The N-benzoylamino acids (1-4) might share similar biosynthetic pathways with the rare siderophore pistillarin. Compounds 1-10 showed antifungal activities (MICs 16-128 mu g/mL) against Fusarium solani, the pathogenic fungus of P. notoginseng. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.