Proprioceptor pathway development is dependent on MATH1
Proprioceptor pathway development is dependent on MATH1
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DOI：
10.1016/s0896-6273(01)00305-1
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发表时间：
2001-05-01
期刊：
影响因子：
16.2
通讯作者：
Zoghbi, HY
中科院分区：
文献类型：
--
作者：
Bermingham, NA;Hassan, BA;Zoghbi, HY
本体感觉系统向丘脑、皮层、脑桥核和小脑提供肢体和身体的连续位置信息。我们之前表明，基本的螺旋-环-螺旋转录因子Math1对本体感觉通路的某些成分的发育至关重要，包括内耳毛细胞、小脑颗粒神经元和脑桥核。在这里，我们证明了Math1缺失的胚胎缺乏D1中间神经元，这些中间神经元产生本体感受器中间神经元和脊髓小脑束和小脑小脑束的一个子集。我们还鉴定了Math1的三个下游基因（Lh2A、Lh2B和Barhl1），并确定Math1控制本体感觉通路多个组分的发展。
The proprioceptive system provides continuous positional information on the limbs and body to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the basic helix-loop-helix transcription factor Math1 is essential for the development of certain components of the proprioceptive pathway, Including inner-ear hair cells, cerebellar granule neurons, and the pontine nuclei. Here, we demonstrate that Math1 null embryos lack the D1 interneurons and that these interneurons give rise to a subset of proprioceptor interneurons and the spinocerebellar and cuneocerebellar tracts. We also identify three downstream genes of Math1 (Lh2A, Lh2B, and Barhl1) and establish that Math1 governs the development of multiple components of the proprioceptive pathway.