Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells
Cloning of BRAK, a novel divergent CXC chemokine preferentially expressed in normal versus malignant cells
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DOI：
10.1006/bbrc.1999.0257
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发表时间：
1999-02-24
影响因子：
3.1
通讯作者：
Hou, YH
中科院分区：
文献类型：
--
作者：
Hromas, R;Broxmeyer, HE;Hou, YH
趋化因子是一个相关蛋白家族，可调节白细胞浸润到发炎组织中，并在许多疾病过程中发挥重要作用。根据其氨基末端半胱氨酸周围的序列，趋化因子分为两大类：CC 或 CXC。我们报道了一种新型人类趋化因子 BRAK 的 PCR 克隆，该趋化因子最初是从乳腺和肾细胞中分离出来的。这种新型趋化因子与其他 CXC 趋化因子关系较远（与 MIP-2 α 和 β 具有 30% 的同一性），并且具有多种生物活性。 BRAK 在正常组织中广泛且高度表达。然而，它仅在 18 种癌细胞系中的 2 种中表达。 BRAK 位于人类染色体 5q31 上。 (C) 1999 年学术出版社。
Chemokines are a family of related proteins that regulate leukocyte infiltration into inflamed tissue and play important roles in many disease processes. Chemokines are divided into two major groups, CC or CXC, based on their sequence around the amino terminal cysteines. We report the PCR cloning of a novel human chemokine termed BRAK for its initial isolation from breast and kidney cells. This novel chemokine is distantly related to other CXC chemokines (30% identity with MIP-2 alpha and beta) and shares several biological activities. BRAK is expressed ubiquitously and highly in normal tissue. However, it was expressed in only 2 of 18 cancer cell lines. BRAK is located on human chromosome 5q31. (C) 1999 Academic Press.