The Relationship Among Gastrointestinal Symptoms, Problem Behaviors, and Internalizing Symptoms in Children and Adolescents With Autism Spectrum Disorder
The Relationship Among Gastrointestinal Symptoms, Problem Behaviors, and Internalizing Symptoms in Children and Adolescents With Autism Spectrum Disorder
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DOI：
10.3389/fpsyt.2019.00194
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发表时间：
2019-04-09
影响因子：
4.7
通讯作者：
Beversdorf, David Q.
中科院分区：
文献类型：
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作者：
Ferguson, Bradley J.;Dovgan, Kristen;Beversdorf, David Q.
背景：许多自闭症谱系障碍 (ASD) 患者同时出现胃肠道 (GI) 症状，但其病因尚不清楚。这些胃肠道症状通常与问题行为和内化症状同时发生，从而降低了这些人的生活质量。方法：本研究以密苏里大学汤普森自闭症和神经发育障碍中心的 340 名 ASD 儿童和青少年为样本，考察了胃肠道问题、问题行为和内化症状之间的关系。结果：大多数患者都经历过便秘 (65%)，大约一半经历过胃痛或胃痛(47.9%)，其他人经历过恶心(23.2%)或腹泻(29.7%)。有攻击性问题行为的幼儿同时出现恶心的可能性要高出 11.2%；然而，年龄较大的儿童表现出内化症状和胃肠道症状之间更复杂的关系。焦虑症状较重的年龄较大的儿童出现便秘的可能性增加 11%，但出现胃痛的可能性减少 9%。性格孤僻的年龄较大的儿童出现胃痛的可能性高 10.9%，但出现便秘的可能性低 8.7%。身体不适较多的年龄较大的儿童出现恶心的可能性高出 11.4%，出现胃痛的可能性高出 11.5%。 结论：结果表明，患有自闭症谱系障碍的幼儿和年龄较大的儿童之间，与胃肠道问题相关的外化问题行为和内化症状的表现有所不同。因此，不同年龄的行为可能与胃肠道症状有不同的关系，这可能对自闭症谱系障碍胃肠道紊乱的治疗和临床方法具有影响。
Background: Many individuals with autism spectrum disorder (ASD) have co-occurring gastrointestinal (GI) symptoms, but the etiology is poorly understood. These GI symptoms often coincide with problem behaviors and internalizing symptoms, which reduces the quality of life for these individuals.Methods: This study examined the relationships among GI problems, problem behaviors, and internalizing symptoms in a sample of 340 children and adolescents with ASD who are patients at the University of Missouri Thompson Center for Autism & Neurodevelopmental Disorders.Results: The majority of patients experienced constipation (65%), about half experienced stomachaches or stomach pain (47.9%), and others experienced nausea (23.2%) or diarrhea (29.7%). Young children with aggressive problem behaviors were 11.2% more likely to have co-occurring nausea; whereas, older children showed more complex relationships between internalizing symptoms and GI symptoms. Older children with greater anxiety symptoms were 11% more likely to experience constipation, but 9% less likely to experience stomachaches. Older children with greater withdrawn behavior were 10.9% more likely to experience stomachaches, but 8.7% less likely to experience constipation. Older children with greater somatic complaints were 11.4% more likely to experience nausea and 11.5% more likely to experience stomachaches.Conclusions: Results suggest that the presentation of externalizing problem behavior and internalizing symptoms associated with GI problems differs between young children and older children with ASD. Therefore, behavior may have different relationships with GI symptoms at different ages, which may have implications for the treatment of and clinical approach to GI disturbances in ASD.