The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases
The role of Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) in lymphoproliferative diseases
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DOI：
10.1006/scbi.1998.0118
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发表时间：
1999-06-01
影响因子：
14.5
通讯作者：
Knowles, DM
中科院分区：
文献类型：
--
作者：
Cesarman, E;Knowles, DM
卡波西肉瘤相关疱疹病毒（KSHV），也称为人类疱疹病毒8 (HHV-8)，已被发现存在于淋巴增生性疾病的有限亚群中。其中包括原发性积液淋巴瘤，以前称为体腔淋巴瘤，是一种罕见的恶性淋巴瘤，具有一系列不寻常的临床和生物学特征，表明它们是一种独特的疾病实体。这种病毒也存在于很大比例的多中心Castleman病病例中，特别是与艾滋病毒感染有关的病例。此外，KSHV与多发性骨髓瘤的发病机制有关，已在骨髓贴壁细胞中发现，但在肿瘤骨髓瘤浆细胞群中未发现。然而，后一项发现仍然存在争议。在恶性淋巴瘤的一个亚群中发现KSHV使得淋巴瘤细胞系得以发展，这些细胞系现在作为病毒繁殖的生物试剂，作为血清学分析的底物，以及作为病理生物学研究的模型系统。本文综述了kshv相关淋巴细胞增生性疾病的特点以及支持其在这些疾病发病机制中的作用的证据。
The Kaposi's sarcoma-associated herpesvirus (KSHV), also called human herpesvirus 8 (HHV-8), has been found to be present in a limited subset of lymphoproliferative disorders. Among these are the primary effusion lymphomas, formerly designated body cavity-based lymphomas, a rare type of malignant lymphoma which possesses an unusual set of clinical and biologic features, suggesting that they represent a distinct disease entity. This virus is also present in a large proportion of cases of multicentric Castleman's disease, particularly those associated with HIV-infection. In addition, KSHV has been implicated in the pathogenesis of multiple myeloma, where it has been identified in bone marrow adherent cells but not in the neoplastic myeloma plasma cell population. However, the latter finding remains controversial. The discovery of KSHV in a subset of malignant lymphomas has allowed the development of lymphoma cell lines which now serve as biological reagents for propagating the virus, as a substrate for serologic assays, and as a model system for pathobiologic studies. This review discuses the features of KSHV-associated lymphoproliferative disorders and the evidence supporting its role in the pathogenesis of these diseases.