Protective effects of extract of Coeloglossum viride var bracteatum on ischemia-induced neuronal death and cognitive impairment in rats
Protective effects of extract of Coeloglossum viride var bracteatum on ischemia-induced neuronal death and cognitive impairment in rats
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DOI：
10.1097/fbp.0b013e3282feb0ac
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发表时间：
2008-07-01
影响因子：
1.6
通讯作者：
Zhang, Jianjun
中科院分区：
文献类型：
--
作者：
Ma, Bo;Li, Min;Zhang, Jianjun
我们的前期研究表明，Coeloglossum viride（L.）哈特姆变种bracteatum（Willd.）提取物（CE）显着改善了由永久性双血管闭塞引起的小鼠记忆受损。为了研究CE长期治疗是否会影响脑缺血诱导的神经元和认知障碍，我们研究了CE对两种不同类型脑损伤的影响：短暂性大脑中动脉闭塞模型局灶性脑缺血;四血管闭塞模型短暂性全前脑缺血。CE治疗（5 mg/kg，口服）显着减少病变体积，并改善被动回避和旋转棒运动任务的表现在短暂的大脑中动脉闭塞大鼠。在四血管闭塞模型中，给予CE的大鼠海马CA 1区神经元细胞丢失显著减少，Morris水迷宫中的表现显著改善。我们的结论是，治疗与CE衰减学习和记忆缺陷，运动功能障碍，和神经元细胞丢失引起的全球或局灶性脑缺血。这些结果表明，CE可能是一个潜在的候选人，用于治疗血管性痴呆。行为药理学19：325-333（c）2008年沃尔特斯·克鲁沃健康垂直酒吧Lippincott威廉姆斯&威尔金斯。
Our earlier study demonstrated that Coeloglossum viride (L.) Hartm. var. bracteatum (Willd.) extract (CE) significantly improved the impaired memory in mice caused by permanent two-vessel occlusion. To investigate whether chronic treatment with CE could influence cerebral ischemia-induced neuronal and cognitive impairments, we examined the effects of CE on two different kinds of cerebral injury: transient middle cerebral artery occlusion model of focal cerebral ischemia; four-vessel occlusion model of transient global forebrain ischernia. CE treatment (5 mg/kg, orally) significantly reduced lesion volume, and improved the performance of passive avoidance and rotarod motor tasks in transient middle cerebral artery occlusion rats. In the four-vessel occlusion model, neuronal cell loss in CA1 of hippocampus was significantly decreased and the performance in the Morris water maze was significantly improved in rats administered CE. We conclude that treatment with CE attenuated learning and memory deficits, motor functional disability, and neuronal cell loss induced by global or focal cerebral ischernia. These results suggest that CE may be a potential candidate for the treatment of vascular dementia. Behavioural Pharmacology 19:325-333 (c) 2008 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.