The level of NPY receptor mRNA expression in diet-induced obese and resistant mice
The level of NPY receptor mRNA expression in diet-induced obese and resistant mice
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DOI：
10.1016/s0169-328x(03)00174-8
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发表时间：
2003-07-04
期刊：
影响因子：
--
通讯作者：
Storlien, LH
中科院分区：
文献类型：
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作者：
Huang, XF;Han, M;Storlien, LH
一些老鼠变得肥胖，而另一些老鼠在高能量饮食中保持苗条。本研究检测了慢性高能量饮食诱导的肥胖（1310）和抵抗（DR）小鼠下丘脑弓状核（Arc）神经肽Y（NPY）、Y1、Y2、Y 5和瘦素受体mRNA的表达水平。将40只小鼠分为两组，喂食高脂肪（HF：40%的热量来自脂肪，20%的热量来自饱和脂肪; n=34）或低脂肪（LF：10%的热量来自脂肪，1%来自饱和脂肪; n=6）饮食。喂养22周后，DIO小鼠的内脏脂肪堆积比DR小鼠高69%，前者表现出中等水平的葡萄糖耐受不良。DIO小鼠的NPY和瘦素受体mRNA表达水平显著高于LF小鼠（分别为+32和+14%，P
Some mice become obese whereas others remain lean when raised on a high-energy diet. This study examined the levels of neuropeptide Y (NPY), and of Y1, Y2, Y5 and leptin receptor mRNA expression in the hypothalamic arcuate nucleus (Arc) of chronic high-energy diet-induced obese (1310) and resistant (DR) mice. Forty mice were divided into two groups and fed either a high-fat (HF: 40% of calories from fat, 20% of calories from saturated fat; n=34) or low-fat (LF: 10% of calories from fat, 1% from saturated fat; n=6) diet. After 22 weeks of feeding, visceral fat accumulation was 69% higher in DIO mice compared with DR mice, and the former showed a moderate level of glucose intolerance. In DIO mice, the levels of NPY and leptin receptor mRNA expressions were significantly higher than in LF mice (+32 and +14%, P