Phantom-based standardization of CT angiography images for spot sign detection.
Phantom-based standardization of CT angiography images for spot sign detection.
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DOI：
10.1007/s00234-017-1857-4
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发表时间：
2017-09
期刊：
影响因子：
2.8
通讯作者：
ATACH-II and NETT Investigators
中科院分区：
文献类型：
--
作者：
Morotti A;Romero JM;Jessel MJ;Hernandez AM;Vashkevich A;Schwab K;Burns JD;Shah QA;Bergman TA;Suri MFK;Ezzeddine M;Kirmani JF;Agarwal S;Shapshak AH;Messe SR;Venkatasubramanian C;Palmieri K;Lewandowski C;Chang TR;Chang I;Rose DZ;Smith W;Hsu CY;Liu CL;Lien LM;Hsiao CY;Iwama T;Afzal MR;Cassarly C;Greenberg SM;Martin RH;Qureshi AI;Rosand J;Boone JM;Goldstein JN;ATACH-II and NETT Investigators
The CT angiography (CTA) spot sign is a strong predictor of hematoma expansion in intracerebral hemorrhage (ICH). However, CTA parameters vary widely across centers and may negatively impact spot sign accuracy in predicting ICH expansion. We developed a CT iodine calibration phantom that was scanned at different institutions in a large multicenter ICH clinical trial to determine the effect of image standardization on spot sign detection and performance. A custom phantom containing known concentrations of iodine was designed and scanned using the stroke CT protocol at each institution. Custom software was developed to read the CT volume datasets and calculate the Hounsfield Unit as a function of iodine concentration for each phantom scan. CTA images obtained within 8 h from symptom onset were analyzed by two trained readers comparing the calibrated vs. uncalibrated density cutoffs for spot sign identification. ICH expansion was defined as hematoma volume growth >33%. A total of 90 subjects qualified for the study, of whom 17/83 (20.5%) experienced ICH expansion. The number of spot sign positive scans was higher in the calibrated analysis (67.8% vs 38.9% p<0.001). All spot signs identified in the non-calibrated analysis remained positive after calibration. Calibrated CTA images had higher sensitivity for ICH expansion (76% vs 52%) but inferior specificity (35% vs 63%) compared with uncalibrated images. Normalization of CTA images using phantom data is a feasible strategy to obtain consistent image quantification for spot sign analysis across different sites and may improve sensitivity for identification of ICH expansion.
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DOI：
10.3174/ajnr.a4810
发表时间：
2016-10
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Morotti A;Romero JM;Jessel MJ;Brouwers HB;Gupta R;Schwab K;Vashkevich A;Ayres A;Anderson CD;Gurol ME;Viswanathan A;Greenberg SM;Rosand J;Goldstein JN
通讯作者：
Goldstein JN
影响因子：
1.2
作者：
Morotti, Andrea;Goldstein, Joshua N.
通讯作者：
Goldstein, Joshua N.
DOI：
10.1056/nejmoa1603460
发表时间：
2016-09-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
Qureshi AI;Palesch YY;Barsan WG;Hanley DF;Hsu CY;Martin RL;Moy CS;Silbergleit R;Steiner T;Suarez JI;Toyoda K;Wang Y;Yamamoto H;Yoon BW;ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network
通讯作者：
ATACH-2 Trial Investigators and the Neurological Emergency Treatment Trials Network
影响因子：
3.5
作者：
Qureshi AI;Palesch YY
通讯作者：
Palesch YY
影响因子：
8.3
作者：
Wada, Ryan;Aviv, Richard I.;Symons, Sean P.
通讯作者：
Symons, Sean P.