1H- and 13C-NMR spectral investigation on amphidinolide A, an antileukemic marine macrolide
1H- and 13C-NMR spectral investigation on amphidinolide A, an antileukemic marine macrolide
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抗白血病海洋大环内酯 Amphidinolide A 的 1H 和 13C-NMR 光谱研究
DOI：
10.1021/np50077a039
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发表时间：
1991
影响因子：
5.1
通讯作者：
H. Hirota
中科院分区：
文献类型：
--
作者：
J. Kobayashi;M. Ishibashi;H. Hirota
amphidinolide A是一种从培养的Amphidinium属海洋共生鞭毛藻中分离出来的抗白血病的20元大环内酯，我们利用2D nmr技术（包括‘ h -’Hcosy, noesi， HMQC和HMBC实验）广泛研究了amphidinolide A的nmr光谱，以证实先前提出的结构1。在noesi数据的基础上，提出了两萜内酯a的立体结构图。
The nmr spectra of amphidinolide A, an antileukemic 20-membered mac-rolide isolated from a cultured symbiotic marine dinoflagellate of the genus Amphidinium, were extensively investigated by utilizing 2D nmr techniques including'H-'Hcosy, NOESY, HMQC, and HMBC experiments to substantiate the previously proposed structure 1. On the basis of the NOESY data a stereostructure la of amphidinolide A was proposed.