The evolution of fibrin-specific targeting strategies
The evolution of fibrin-specific targeting strategies
复制标题
DOI：
10.1039/c4tb01769b
复制
发表时间：
2015-01-01
影响因子：
7
通讯作者：
Barker, Thomas H.
中科院分区：
文献类型：
--
作者：
Stefanelli, Victoria L.;Barker, Thomas H.
纤维蛋白特异性靶向能力由于其对生物分子递送、诊断和再生医学的影响而被高度寻求了50多年。然而，直到最近，我们对纤维蛋白复杂的聚合动力学和生物相互作用的充分了解才开始被充分利用，以追求这一目标。这一重点将讨论一系列快速变化的战略，专门针对纤维蛋白的前体纤维蛋白原和这些方法的优点和缺点，为各种应用。
Fibrin-specific targeting capabilities have been highly sought for over 50 years due to their implications for bio-molecule delivery, diagnostics, and regenerative medicine. Yet only recently has our full knowledge of fibrin's complex polymerization dynamics and biological interactions begun to be fully exploited in pursuit of this goal. This highlight will discuss the range of rapidly changing strategies for specifically targeting fibrin over the precursor fibrinogen and the advantages and disadvantages of these approaches for various applications.