Environmental factors during postnatal period modify activity and non-selective attention in the Naples High-Excitability rat
Environmental factors during postnatal period modify activity and non-selective attention in the Naples High-Excitability rat
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DOI：
10.1016/s0166-4328(01)00426-0
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发表时间：
2002-03-10
影响因子：
2.7
通讯作者：
Sadile, AG
中科院分区：
文献类型：
--
作者：
Fresiello, A;Grammatikopoulos, G;Sadile, AG
已经在多动和注意力缺陷动物模型——那不勒斯高兴奋性大鼠（NHE）中研究了表观遗传因素在活动和注意力过程背后的神经系统表型表达中的参与。为了实现这一目标，雄性 NHE 幼崽在出生后的前 4 周内以较小的窝数（四窝）或正常窝数（九窝）进行饲养。两组均接受每周一次、两次或四次的差别处理程序。断奶后（28天），将大鼠分成两组饲养，并在成年后测试其在空间新奇情况下的活动和非选择性注意力，以24小时为间隔进行连续3次测试。该行为被录像并离线分析过角和站立的频率以及站立的持续时间。结果表明，产仔数少导致的母性护理增加和高脂肪饮食对活动和饲养期持续时间产生了长期持续的影响，而饲养期的活动和持续时间表明非选择性注意力。这些效应很复杂，因为差异化处理仅在低刺激水平下才有益。因此，这些发现表明，在产后发育关键时期起作用的表观因素可能与遗传决定因素相互作用，进而影响控制活动、定向和扫描时间的神经系统的成熟。 (C) 2002 Elsevier Science B.V. 保留所有权利。
The involvement of epigenetic factors in the phenotypic expression of the neural systems underlying activity and attentive processes has been investigated in an animal model of hyperactivity and attention-deficit, the Naples High-Excitability rat (NHE). To this aim, male NHE pups have been reared in small (four) or normal litter size (nine) during the first 4 weeks of postnatal life. Both groups underwent a differential handling procedure occurring once, twice or four times a week. After weaning (28 days), rats were housed in groups of two and tested as young adults for activity and non-selective attention in a spatial novelty situation for three consecutive tests at 24-h intervals. The behaviour was videotaped and analysed off line for the frequency of corner crossings and rearings and duration of rearings. The results indicate that the increased maternal care and high fat diet induced by the small litter size produced long lasting effects on activity and duration of rearing episodes that indexes non-selective attention. These effects were complex as differential handling was beneficial only at low stimulation level. Thus, these findings suggest that epigenctic factors acting during critical periods of post-natal development may interact with genetic determinants that in turn influence the maturation of the neural systems controlling activity, orienting and scanning time. (C) 2002 Elsevier Science B.V. All rights reserved.