Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain.
Cadmium-Induced Cytotoxicity: Effects on Mitochondrial Electron Transport Chain.
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DOI：
10.3389/fcell.2020.604377
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发表时间：
2020
影响因子：
5.5
通讯作者：
Becatti M
中科院分区：
文献类型：
--
作者：
Branca JJV;Pacini A;Gulisano M;Taddei N;Fiorillo C;Becatti M
镉（Cd）是世界范围内众所周知的重金属和环境毒物和污染物，大量存在于各种物品中，例如塑料（玩具）、电池、油漆、陶瓷、污染的水、空气、土壤、食物、肥料和香烟烟雾。如今，它是科学界的一个重要研究领域，主要是因为它对公众健康的影响。由于镉的半衰期在15至30年之间，镉具有在器官和组织中积累的能力，产生有害影响。因此，即使在低剂量，镉长期暴露可能会导致多器官毒性。线粒体是镉诱导细胞毒性的关键细胞内靶点，但其潜在机制尚未完全阐明。本综述旨在阐明镉对线粒体，特别是对线粒体电子传递链的影响。
Cadmium (Cd) is a well-known heavy metal and environmental toxicant and pollutant worldwide, being largely present in every kind of item such as plastic (toys), battery, paints, ceramics, contaminated water, air, soil, food, fertilizers, and cigarette smoke. Nowadays, it represents an important research area for the scientific community mainly for its effects on public health. Due to a half-life ranging between 15 and 30 years, Cd owns the ability to accumulate in organs and tissues, exerting deleterious effects. Thus, even at low doses, a Cd prolonged exposure may cause a multiorgan toxicity. Mitochondria are key intracellular targets for Cd-induced cytotoxicity, but the underlying mechanisms are not fully elucidated. The present review is aimed to clarify the effects of Cd on mitochondria and, particularly, on the mitochondrial electron transport chain.