Bacteriological study of diabetic foot infections
Bacteriological study of diabetic foot infections
复制标题
DOI：
10.1016/j.jdiacomp.2004.06.001
复制
发表时间：
2005-05-01
影响因子：
3
通讯作者：
Mobasher, LA
中科院分区：
文献类型：
--
作者：
Abdulrazak, A;Bitar, ZI;Mobasher, LA
目的：糖尿病足感染的多微生物性质已在文献中有很好的记录。未接触抗生素的糖尿病足感染患者以前没有得到很好的研究。研究了从未暴露于抗菌剂30天的社区获得性足部感染中培养的细菌分离株的相对频率。此外，还评估了细菌对常用抗菌剂的体外敏感性。研究方法：这是一项前瞻性研究，其中在阿丹教学医院糖尿病足诊所就诊的86名连续糖尿病患者的感染伤口在就诊时进行了培养。患者在接受培养前30天未接受抗菌治疗。采用需氧和厌氧微生物技术培养标本。检测分离株对常用抗菌治疗的敏感性。结果：金黄色葡萄球菌是最常见的病原菌，占38.4%。其他微生物为铜绿假单胞菌（17.5%）和奇异变形杆菌（18%），厌氧革兰氏阴性菌（10.5%），主要是脆弱拟杆菌。亚胺培南、美罗培南和头孢吡肟是对革兰阴性菌最有效的药物。万古霉素对革兰氏阳性菌最有效。结论：S. aureus和R.铜绿假单胞菌是糖尿病足感染的最常见原因。厌氧菌仍然是感染的常见原因，尽管患病率较低。这些伤口可能需要使用联合抗菌治疗进行初始管理。(c)2005年爱思唯尔公司All rights reserved.
Aims: The polymicrobial nature of diabetic foot infection has been well documented in the literature. Patients with diabetic foot infection not exposed to antibiotics are not well studied before. The relative frequency of bacterial isolates cultured from community-acquired foot infections that are not exposed to antimicrobial agents for 30 days is studied. In addition, the bacterial comparative in vitro susceptibility to the commonly used antibacterial agents is assessed. Methods: This is a prospective study in which the infected wounds of 86 consecutive diabetic patients seen in the diabetic foot clinic in Adan Teaching Hospital were cultured when visiting the clinic. The patients did not receive antimicrobial therapy 30 days prior to taking the cultures. The specimen was cultured using aerobic and anaerobic microbiological techniques. Isolates were tested for susceptibility to commonly used antimicrobial therapy. Result: Staphylococcus aureus was the most common isolate, being recovered from 38.4% of cases. Other organisms were Pseudomonas aeruginosa (17.5%) and Proteus mirabilis (18%), anaerobic gram-negative organisms (10.5%), mainly Bacteroides fragilis. Imipenem, meropenem, and cefepime were the most effective agents against gram-negative organisms. Vancomycin was the most effective against gram-positive organisms. Conclusion: S. aureus and R. aeruginosa were the most common causes of diabetic foot infections. Anaerobic organisms are still a common cause for infection, although the prevalence is less. These wounds may require use of combined antimicrobial therapy for initial management. (c) 2005 Elsevier Inc. All rights reserved.