1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT) and reduced bone mineral density
1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT) and reduced bone mineral density
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DOI：
10.1080/00039890009603403
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发表时间：
2000-05-01
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影响因子：
--
通讯作者：
Bronks, R
中科院分区：
文献类型：
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作者：
Beard, J;Marshall, S;Bronks, R
有机氯农药1,1,1-三氯-2,2-双（对氯苯）-乙烷（DDT），是一种众所周知且广泛分布的“环境雌激素”(世界卫生组织标准编号：9;日内瓦，瑞士[1979])。Kelce等人（Nature, 1995; 375:581-85）最近发现滴滴涕代谢物1,1-二氯-2,2-二（对氯苯基）乙烯（DDE）最近也被确定为一种有效的雄激素受体拮抗剂。作者研究了68名饮食中钙摄入充足的久坐女性的血清DDE水平与骨密度之间的关系。骨密度降低与年龄显著相关（r = - 0.36, p = 0.004），与血清DDE水平的log升高显著相关（r = - 0.27, p = 0.03）。作者还使用多元回归分析来检验其他预测变量对对数DDE与骨密度之间关系的影响。最强的模型（p = .002）包括对数DDE （p = .018）、年龄（p = .002）和激素替代治疗年数（p = .10）作为预测变量，该模型可以预测21%的骨矿物质密度变化。这些结果表明，过去社区接触滴滴涕可能与妇女骨密度降低有关。
The organochlorine pesticide 1,1,1-trichloro-2,2-bis (p-chlorophenyl)-ethane (DDT), is a well-known and widely dispersed "environmental estrogen" (World Health Organization Criteria no. 9; Geneva, Switzerland [1979]). Kelce et al. (Nature, 1995; 375:581-85) recently identified the DDT metabolite, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), has also recently been identified as a potent androgen receptor antagonist. The authors examined the relationship between serum levels of DDE and bone mineral density in 68 sedentary women who reported adequate dietary intake of calcium. Reduced bone mineral density was correlated significantly with age (r = -.36, p = .004), as well as with increases in the log of DDE levels in serum (r = -.27, p = .03). The authors also used multiple-regression analysis to examine the influence of other predictor variables on the relationship between log DDE and bone mineral density. The strongest model (p = .002) included log DDE (p = .018), age (p = .002), and years on hormone replacement therapy (p = .10) as predictor variables, and this model afforded prediction of 21% of bone mineral density variation. These results suggest that past community exposures to DDT may be associated with reduced bone mineral density in women.