Activating transcription factor 3 mRNA is upregulated in primary cultures of trigeminal ganglion neurons
Activating transcription factor 3 mRNA is upregulated in primary cultures of trigeminal ganglion neurons
复制标题
DOI：
10.1016/s0169-328x(03)00335-8
复制
发表时间：
2003-10-21
期刊：
影响因子：
--
通讯作者：
Flores, CM
中科院分区：
文献类型：
--
作者：
Dussor, GO;Price, TJ;Flores, CM
激活转录因子 3 (ATF3) 已被用作初级感觉神经元神经损伤的标志物。本研究的目的是确定培养物中的初级感觉神经节是否表达 ATF3，从而表达受损的表型。在铺板后的所有时间点（1小时至14天），培养物中的神经元均表达ATF3，而在天然神经节中则检测不到表达。此外，NGF无法挽救这种受伤的表型。因此，培养中的感觉神经元代表了受伤神经元的潜在模型。 (C) 2003 Elsevier B.V. 保留所有权利。
Activating transcription factor 3 (ATF3) has been used in as a marker of nerve injury in primary sensory neurons. The purpose of the present studies was to determine whether primary sensory ganglia in culture express ATF3 and, thus, an injured phenotype. At all time points post-plating (1 h-14 days), neurons in culture expressed ATF3 compared to undetectable expression in native ganglia. In addition, NGF was unable to rescue this injured phenotype. Thus, sensory neurons in culture represent a potential model of injured neurons. (C) 2003 Elsevier B.V. All rights reserved.