COMPARISON OF FENTANYL, SUFENTANIL AND ALFENTANIL DURING AWAKE CRANIOTOMY FOR EPILEPSY
COMPARISON OF FENTANYL, SUFENTANIL AND ALFENTANIL DURING AWAKE CRANIOTOMY FOR EPILEPSY
复制标题
DOI：
10.1007/bf03009510
复制
发表时间：
1993-05-01
期刊：
影响因子：
--
通讯作者：
GELB, AW
中科院分区：
文献类型：
--
作者：
GIGNAC, E;MANNINEN, PH;GELB, AW
在癫痫手术的清醒开颅术中使用Neurolept麻醉。本研究比较了较新的阿片类药物舒芬太尼和阿芬太尼的镇痛，镇静和副作用，与芬太尼在清醒开颅手术患者。将30例患者随机分为三组，每组接受氟哌利多、茶苯海明和所选阿片类药物推注，然后输注。使用的阿片类药物剂量为芬太尼0.75 μ g。kg-1加0.01 μ g。kg-1. min-1;舒芬太尼0.075 μ g. kg-1加0.0015 μ g。kg-1. 最小1毫克，阿芬太尼7.5毫克。kg-1加0.5 μ g. kg-1. min-1。 三组间氟哌利多、茶苯海明的需求量或并发症发生率无差异。所需阿片类药物的总剂量为芬太尼4.9 +/-1.3 μ g。kg-1，舒芬太尼0.6 ± 0.2 μ g. kg-1和阿芬太尼149 +/-36 μ g. kg-1.两名患者变得不合作，需要全身麻醉。所有其他患者的手术、皮质电图和刺激试验条件均令人满意。我们的结论是，较新的阿片类药物没有提供任何好处，
Neurolept anaesthesia is used during awake craniotomy for epilepsy surgery. This study compares analgesia, sedation and the side effects of the newer opioids sufentanil and alfentanil, with those of fentanyl in patients undergoing awake craniotomy. Thirty patients were randomized into three groups, each received droperidol, dimenhydrinate and the chosen opioid as a bolus followed by an infusion. The opioid doses used were fentanyl 0.75 mug . kg-1 plus 0.01 mug . kg-1 . min-1; sufentanil 0.075 mug . kg-1 plus 0.0015 mug . kg-1 . Min-1, and alfentanil 7.5 mug . kg-1 plus 0.5 mug . kg-1 . min-1. There were no differences in the requirements for droperidol, dimenhydrinate or in the incidence of complications among the three groups. The total doses of the opioids required were fentanyl 4.9 +/- 1.3 mug . kg-1, sufentanil 0.6 +/- 0.2 mug . kg-1 and alfentanil 149 +/- 36 mug . kg-1. Two patients became uncooperative requiring general anaesthesia. The conditions for surgery, electrocorticography and for stimulation testing were satisfactory in all other patients. We conclude that the newer opioids did not offer any benefit over