Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents
Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents
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DOI：
10.1093/cercor/bhm003
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发表时间：
2007-12-01
期刊：
影响因子：
3.7
通讯作者：
Ewing-Cobbs, Linda
中科院分区：
文献类型：
--
作者：
Eluvathingal, Thomas J.;Hasan, Khader M.;Ewing-Cobbs, Linda
采用高信噪比、角度和空间分辨率的全脑扩散张量束成像(DTT)技术，对31名6~17岁右利手儿童的6条脑白质通路(弓状束、下纵束、额枕下束、钩状束、皮质脊髓束和躯体感觉通路)的年龄、性别差异和侧向不对称性进行了研究。分数各向异性(FA)是水分子扩散系数方向变化的量度，以及水沿路径的扩散系数(平行、垂直和平均扩散系数)的大小被量化。观察到三种主要的成熟模式：1)FA随年龄显著增加，伴随着所有三种扩散系数的显著降低(例如，左侧IFOF)；2)所有三种扩散系数随年龄显著降低，但FA没有显著变化(例如，左侧CST)；以及3)FA或扩散系数(例如SS)没有明显的年龄相关变化。性别差异很小。许多径路表现为侧向不对称。在右半球，相当多(29%)的受试者无法看到房颤的额颞部(FT)部分。房颤、UF和CST的FT段左半球FA较高，而房颤额顶段FA较低。这项研究为解释儿童健康和疾病中的脑DTT测量提供了必要的标准化数据。
Whole-brain diffusion tensor tractography (DTT) at high signal-to-noise ratio and angular and spatial resolutions were utilized to study the effects of age, sex differences, and lateral asymmetries of 6 white matter pathways (arcuate fasciculus [AF], inferior longitudinal fasciculus, inferior fronto-occipital fasciculus [IFOF], uncinate fasciculus [UF], corticospinal tract [CST], and somatosensory pathway [SS]) in 31 right-handed children (6-17 years). Fractional anisotropy (FA), a measure of the orientational variance in water molecular diffusivity, and the magnitude of water diffusivity (parallel, perpendicular, and mean diffusivity) along the pathways were quantified. Three major patterns of maturation were observed: 1) significant increase in FA with age, accompanied by significant decreases in all 3 diffusivities (e.g., left IFOF); 2) significant decreases in all three diffusivities with age without significant changes in FA (e.g., left CST); and 3) no significant age-related changes in FA or diffusivity (e.g., SS). Sex differences were minimal. Many pathways showed lateral asymmetries. In the right hemisphere, the frontotemporal (FT) segment of AF was not visualized in a substantial (29%) number of participants. FA was higher in the left hemisphere in the FT segment of AF, UF, and CST, whereas it was lower in the frontoparietal segment of AF. This study provides normative data essential for the interpretation of pediatric brain DTT measurements in both health and disease.