The HVC microcircuit: The synaptic basis for interactions between song motor and vocal plasticity pathways
The HVC microcircuit: The synaptic basis for interactions between song motor and vocal plasticity pathways
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DOI：
10.1523/jneurosci.3726-04.2005
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发表时间：
2005-02-23
影响因子：
5.3
通讯作者：
Prather, JF
中科院分区：
文献类型：
--
作者：
Mooney, R;Prather, JF
支配下行运动或基底神经节通路的端脑神经元之间的突触相互作用在复杂运动的学习、计划和执行中是必不可少的。鸣禽端脑核hvcare内的突触相互作用涉及与习得发声相关的运动和听觉活动。HVC包含支配歌唱前运动区的投射神经元（PNs） （HVCRA），支配嗓音可塑性所需的基底神经节通路的其他PNs(HVCX)，以及中间神经元（HVCINT）。在歌唱过程中，HVCRA在短暂的稀疏爆发中放电，可能是由于HVCINT - HVCRA的相互作用，并且在基底神经节通路中可以检测到相应的放电，可能是由于HVCRA向HVCX细胞的突触传递。在歌曲回放过程中，局部相互作用，包括对HVCX细胞的抑制，形成了高度选择性的反应，将HVC与其听觉传入区分开。为了更好地了解HVC运动和听觉特性的突触基质，我们对成年雄性斑胸草雀的HVC神经元进行了细胞内记录，并使用峰值触发平均来评估突触连通性。PNs之间的主要突触相互作用是HVCRA对HVCX的失联抑制，这可能将HVC的两个输出中的歌曲运动信号联系起来，并解释了HVCX细胞中一些歌曲回放引起的抑制。此外，单个中间神经元与两种类型的PN形成不同的连接，任何一种PN都可以与中间神经元形成相互连接。在这两个方面，HVC的突触结构与某些模式生成网络中描述的相似，强调了可能对唱歌和歌曲学习很重要的特征。
Synaptic interactions between telencephalic neurons innervating descending motor or basal ganglia pathways are essential in the learning, planning, and execution of complex movements. Synaptic interactions within the songbird telencephalic nucleusHVCare implicated in motor and auditory activity associated with learned vocalizations. HVC contains projection neurons ( PNs) ( HVCRA) that innervate song premotor areas, other PNs( HVCX) that innervate a basal ganglia pathway necessary for vocal plasticity, and interneurons( HVCINT). During singing, HVCRA fire in temporally sparse bursts, possibly because of HVCINT - HVCRA interactions, and a corollary discharge can be detected in the basal ganglia pathway, likely because of synaptic transmission from HVCRA to HVCX cells. During song playback, local interactions, including inhibition onto HVCX cells, shape highly selective responses that distinguish HVC from its auditory afferents. To better understand the synaptic substrate for the motor and auditory properties of HVC, we made intracellular recordings from pairs of HVC neurons in adult male zebra finch brain slices and used spike- triggered averages to assess synaptic connectivity. A major synaptic interaction between the PNs was a disynaptic inhibition from HVCRA to HVCX, which could link song motor signals in the two outputs of HVC and account for some of the song playback- evoked inhibition in HVCX cells. Furthermore, single interneurons made divergent connections onto PNs of both types, and either PN type could form reciprocal connections with interneurons. In these two regards, the synaptic architecture of HVC resembles that described in some pattern- generating networks, underscoring features likely to be important to singing and song learning.